2. 重组蛋白
  3. Receptor Proteins Biotinylated Proteins
  4. ASGR1/ASGPR1 蛋白, Mouse (Biotinylated, HEK293, His)

ASGR1/ASGPR1 蛋白, Mouse (Biotinylated, HEK293, His)

目录号: HY-P77555
产品使用指南

ASGR1/ASGPR1 蛋白通过介导去唾液酸化血浆糖蛋白的内吞作用并识别末端半乳糖和 N-乙酰半乳糖胺，在细胞过程中发挥至关重要的作用。它促进配体内化和复合物的形成，并转运至分选细胞器。ASGR1/ASGPR1 蛋白, Mouse (Biotinylated, HEK293, His) 是重组的 ASGR1/ASGPR1 蛋白，由 HEK293 表达，带有 N-His 标签。ASGR1/ASGPR1 蛋白, Mouse (Biotinylated, HEK293, His) 全长 225 个氨基酸，分子量约为 ~28 KDa。

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描述

ASGR1/ASGPR1 proteins play a crucial role in cellular processes by mediating endocytosis of desialylated plasma glycoproteins and recognizing terminal galactose and N-acetylgalactosamine. It promotes ligand internalization and formation of complexes that are transported to sorting organelles. ASGR1/ASGPR1 Protein, Mouse (Biotinylated, HEK293, His) is the recombinant mouse-derived ASGR1/ASGPR1 protein, expressed by HEK293 , with N-His labeled tag. The total length of ASGR1/ASGPR1 Protein, Mouse (Biotinylated, HEK293, His) is 225 a.a., with molecular weight of ~28 KDa.
研究背景

ASGR1/ASGPR1 蛋白通过介导血浆糖蛋白的内吞作用在细胞过程中发挥至关重要的作用，血浆糖蛋白在复杂碳水化合物部分上的末端唾液酸残基已被去除。受体对末端半乳糖和 N-乙酰半乳糖胺单元的识别使配体内化，形成复合物，随后被转运至分选细胞器。在该细胞器内，受体和配体解离，ASGR1/ASGPR1 被循环回到细胞膜表面。该蛋白质参与这些动态过程强调了其在糖蛋白的细胞处理中的重要性，并有助于细胞稳态的调节。值得注意的是，ASGR1/ASGPR1 还与 LASS2 相互作用，扩大了其分子关联，并表明其对细胞信号传导或协调的潜在影响。
种属

Mouse
表达系统

HEK293
标签

N-His
蛋白编号

P34927 (S60-N284)
基因 ID

11889  [NCBI]
蛋白结构
N-term
His
ASGR1 (S60-N284)
Accession # P34927
C-term
同用名
ASGPR; ASGPR1; ASGR1; Asialoglycoprotein receptor 1; CLEC4H1; Hepatic lectin H1; MHL1
分子量

Approximately 28 kDa.
纯度

Greater than 95% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

ASGR1/ASGPR1 Protein, Mouse (Biotinylated, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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