AXL 蛋白, Mouse (HEK293, His-Fc)

The AXL protein has predicted roles in various cellular functions, binds to phosphatidylinositol 3-kinase and phosphatidylserine, and serves as a viral receptor. It negatively regulates apoptosis and positively regulates protein kinase B signaling. AXL Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived AXL protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of AXL Protein, Mouse (HEK293, His-Fc) is 424 a.a., with molecular weight of 95-120 kDa.

预计 AXL 蛋白在多种细胞功能中发挥关键作用，包括磷脂酰肌醇 3 激酶结合活性、磷脂酰丝氨酸结合活性和病毒受体活性。AXL 参与细胞凋亡过程的负调节和蛋白激酶 B 信号传导的正调节，在动物器官发育、骨髓细胞稳态和肿瘤坏死因子产生的负调节等多种过程的上游发挥作用。预计 AXL 位于肌动蛋白细胞骨架、细胞表面和宿主细胞表面等细胞成分中，预计将成为质膜的组成部分和受体复合物的一部分。AXL 在消化系统、大脑、泌尿生殖系统、呼吸系统和视觉系统等多种结构中广泛表达，很可能在不同组织的众多生理过程中发挥着至关重要的作用。

Immobilized AXL at 2 μg/mL (100 μL/well) can bind Biotinylated GAS6 protein. The ED₅₀ for this effect is 9.284 ng/mL, corresponding to a specific activity is 1.08×10^5 Unit/mg.

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  Immobilized AXL at 2 μg/mL (100 μL/well) can bind Biotinylated GAS6 protein. The ED₅₀ for this effect is 9.284 ng/mL, corresponding to a specific activity is 1.08×10⁵Unit/mg.

Mouse

HEK293

C-hFc;C-His

NP_033491.2 (H20-P443)

26362  [NCBI]

HKDTQTEAGSPFVGNPGNITGARGLTGTLRCELQVQGEPPEVVWLRDGQILELADNTQTQVPLGEDWQDEWKVVSQLRISALQLSDAGEYQCMVHLEGRTFVSQPGFVGLEGLPYFLEEPEDKAVPANTPFNLSCQAQGPPEPVTLLWLQDAVPLAPVTGHSSQHSLQTPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQRPHHLHVVSRQPTELEVAWTPGLSGIYPLTHCNLQAVLSDDGVGIWLGKSDPPEDPLTLQVSVPPHQLRLEKLLPHTPYHIRISCSSSQGPSPWTHWLPVETTEGVPLGPPENVSAMRNGSQVLVRWQEPRVPLQGTLLGYRLAYRGQDTPEVLMDIGLTREVTLELRGDRPVANLTVSVTAYTSAGDGPWSLPVPLEPWRPGQGQPLHHLVSEPPPRAFSWP

95-120 kDa

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  Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.