2. 重组蛋白
  3. Immune Checkpoint Proteins CD Antigens
  4. Inhibitory Checkpoint Molecules Stimulatory Immune Checkpoint Molecules T Cell CD Proteins B Cell CD Proteins Macrophage CD Proteins Monocyte CD Proteins Dendritic Cell CD Proteins
  5. B7-1/CD80
  6. B7-1/CD80 蛋白, Cynomolgus (242a.a, HEK293, hFc)

B7-1/CD80 蛋白, Cynomolgus (242a.a, HEK293, hFc)

目录号: HY-P75495
产品使用指南

B7-1/CD80 蛋白对于提供 T 淋巴细胞激活至关重要的共刺激信号至关重要。T 细胞增殖和细胞因子产生取决于 CD28 或 CTLA-4 与该受体的结合。作为重要的免疫反应介质，B7-1/CD80 促进 T 细胞和调节受体之间的动态相互作用，影响免疫系统中 T 淋巴细胞激活和调节的重要过程。B7-1/CD80 蛋白, Cynomolgus (242a.a, HEK293, hFc) 是重组的 B7-1/CD80 蛋白，由 HEK293 表达，带有 C-hFc 标签。B7-1/CD80 蛋白, Cynomolgus (242a.a, HEK293, hFc) 全长 242 个氨基酸，分子量分别约为 ~65 & 44 kDa。

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描述

B7-1/CD80 Protein is pivotal in providing the costimulatory signal crucial for T lymphocyte activation. T-cell proliferation and cytokine production hinge on the binding of CD28 or CTLA-4 to this receptor. As a crucial immune response mediator, B7-1/CD80 facilitates dynamic interplay between T cells and regulatory receptors, influencing essential processes for T lymphocyte activation and regulation in the immune system. B7-1/CD80 Protein, Cynomolgus (242a.a, HEK293, hFc) is the recombinant cynomolgus-derived B7-1/CD80 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of B7-1/CD80 Protein, Cynomolgus (242a.a, HEK293, hFc) is 242 a.a., with molecular weight of ~65 & 44 kDa, respectively.
研究背景

B7-1/CD80 蛋白在 T 淋巴细胞激活所需的共刺激信号中发挥着关键作用。T 细胞增殖和细胞因子产生的诱导取决于 CD28 或 CTLA-4 与该受体的结合。作为免疫反应的重要介质，B7-1/CD80 促进 T 细胞与其调节受体之间的动态相互作用，从而影响免疫系统中 T 淋巴细胞激活和调节所必需的关键过程。
种属

Cynomolgus
表达系统

HEK293
标签

C-hFc
蛋白编号

AAC31555 (M1-N242)
基因 ID

105470340  [NCBI]
蛋白结构
N-term
B7-1 (M1-N242)
Accession # AAC31555
hFc
C-term
同用名
T-lymphocyte activation antigen CD80; Activation B7-1 antigen; BB1; B7; CD80; CD28LG; LAB7
分子量

Approximately 65&44 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

B7-1/CD80 Protein, Cynomolgus (242a.a, HEK293, hFc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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