2. 重组蛋白
  3. Immune Checkpoint Proteins CD Antigens
  4. Stimulatory Immune Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins
  5. B7-H2/ICOSLG B7-H2/CD275
  6. B7-H2/ICOSLG 蛋白, Cynomolgus (HEK293, Fc)

B7-H2/ICOSLG 蛋白, Cynomolgus (HEK293, Fc)

目录号: HY-P76394
产品使用指南

B7-H2 是诱导共刺激物的配体，是人类 CD28 和 CTLA-4 的配体，而这些相互作用在小鼠中不保守。B7-H2 在非重叠域中与 CD28 相互作用。B7-H2 通过 CD28 诱导生存因子 Bcl-xL、下调细胞周期抑制剂 p27kip1 共刺激并触发 ERK 和 AKT 激酶依赖性途径的信号级联。B7-H2/ICOSLG 蛋白, Cynomolgus (HEK293, Fc) 是重组的 B7-H2/ICOSLG 蛋白，由 HEK293 表达，带有 C-hFc 标签。B7-H2/ICOSLG 蛋白, Cynomolgus (HEK293, Fc) 全长 256 个氨基酸，分子量约为 ~53.3 KDa。

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描述

B7-H2 is the ligand of Inducible Costimulator, was a ligand for CD28 and CTLA-4 in human, whereas these interactions were not conserved in mouse. B7-H2 interacted with CD28 in a non-overlapping domain. B7-H2 costimulation via CD28 induced survival factor Bcl-xL, downregulated cell cycle inhibitor p27kip1 and triggered signaling cascade of ERK and AKT kinases-dependent pathways[1][2]. B7-H2/ICOSLG Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-hFc labeled tag. The total length of B7-H2/ICOSLG Protein, Cynomolgus (HEK293, Fc) is 256 a.a., with molecular weight of ~53.3 KDa.
研究背景

B7-H2 与 B7-1 和 B7-2 一样在非重叠结构域中与 CD28 相互作用，对于人类 T 细胞对同种异体抗原的初级反应和记忆回忆反应的共刺激至关重要。B7-H2 是 CD28 的共刺激配体。B7-H2 和 B7-1 或 B7-2 结合 CD28 的非竞争性表明这些配体可以独立、同时甚至协同作用，为 T 细胞提供最大程度的 CD28 共刺激[1]。
种属

Cynomolgus
表达系统

HEK293
标签

C-hFc
蛋白编号

XP_005548618 (M1-T256)
基因 ID

102132485  [NCBI]
蛋白结构
N-term
B7-H2 (M1-T256)
Accession # XP_005548618
hFc
C-term
同用名
ICOS ligand; B7-H2; ICOSLG; LICOS; B7RP-1; CD275
分子量

Approximately 53.3 kDa.
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

B7-H2/ICOSLG Protein, Cynomolgus (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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