B7-H4 蛋白, Rhesus macaque (HEK293, Fc)

B7-H4 Protein, Rhesus macaque (HEK293, Fc) may participate in negative regulation of cell-mediated immunity in peripheral tissues. Cell-associated B7-H4 could also inhibit T cell response. B7-H4 acts as a morphogenic factor for cancer cells^[1][2][3].

人 B7-H4 mRNA 在脾、肺和胸腺中表达。体外刺激后，可在 T 细胞、B 细胞、单核细胞和 DC 上诱导 B7-H4 表达。^[1]。
在心脏、肺、肝脏、骨骼肌、肾脏和睾丸中检测到小鼠 B7-H4 转录物，但在大脑和脾脏中未检测到^{[1]< /sup>.
B7-H4 是一种癌症促进剂，也是一个潜在的重要治疗靶点[3]。}

Rhesus Macaque

HEK293

C-Fc

F7B770 (F29-A258)

714123  [NCBI]

FGISGRHSITVTTVASAGNIGEDGILSCTFEPDIKLSDIVIQWLKEGVIGLVHEFKEGKDELSEQDEMFRGRTAVFADQVIVGNASLRLKNVQLTDAGTYKCYIITSKGKGNANLEYKTGAFSMPEVNVDYNASSETLRCEAPRWFPQPTVVWASQVDQGANFSEVSNTSFELNSENVTMKVVSVLYNVTINNTYSCMIENDIAKATGDIKVTESEIKRRSHLQLLNSKA-Fctag

70-100 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Gabriel L Sica, et al. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity. 2003 Jun;18(6):849-61.  [Content Brief]

  [2]. Joseph R Podojil, et al. Potential targeting of B7-H4 for the treatment of cancer. Immunol Rev. 2017 Mar;276(1):40-51.  [Content Brief]

  [3]. Yun Qian, et al. B7-H4 enhances oncogenicity and inhibits apoptosis in pancreatic cancer cells. Cell Tissue Res. 2013 Jul;353(1):139-51.  [Content Brief]