BLOC1S2 蛋白, Human (GST)

BLOC1S2, a vital BLOC-1 complex component, is crucial for lysosome-related organelle (LRO) biogenesis, including platelet dense granules and melanosomes. Collaborating with the AP-3 complex, BLOC-1 directs membrane protein cargos into vesicles for delivery into neurites and nerve terminals, implicating it in neurite extension. As part of the BORC complex, BLOC1S2 contributes to lysosome movement and localization, potentially recruiting ARL8B. It may also influence cell proliferation within the BLOC-1 and BORC complexes, interacting with various components. BLOC1S2 Protein, Human (GST) is the recombinant human-derived BLOC1S2 protein, expressed by E. coli, with N-GST labeled tag. The total length of BLOC1S2 Protein, Human (GST) is 99 a.a., with molecular weight of ~11.35 KDa.

BLOC1S2 蛋白是 BLOC-1 复合物的重要组成部分，对于溶酶体相关细胞器 (LRO)（包括血小板致密颗粒和黑素体）的正常生物发生至关重要。BLOC-1 复合物与 AP-3 复合物一起，对于将膜蛋白货物引导到细胞体形成的囊泡中至关重要，从而促进它们递送到神经突和神经末梢。BLOC-1 复合物与 SNARE 蛋白结合也参与神经突延伸。作为 BORC 复合体的一部分，BLOC1S2 可能有助于溶酶体在细胞外周的运动和定位，与溶酶体的胞质面相关联，并可能招募 ARL8B 将溶酶体与微管正端定向驱动蛋白马达偶联。此外，BLOC1S2 可能在细胞增殖中发挥作用，作为溶酶体相关细胞器复合物 1 (BLOC-1) 和 BLOC-one 相关复合物 (BORC) 生物发生的一部分，与这些复合物内的各种成分相互作用，包括 BLOC1S1、 BLOC1S3、BLOC1S4、BLOC1S5、SNAPIN 和 IFT57。

Human

E. coli

N-GST

Q6QNY1-2 (M1-R99)

282991  [NCBI]

Approximately 11.35 kDa.

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.