2. 重组蛋白
  3. Complement System
  4. Complement Component 7
  5. C7/Complement component C7 蛋白, Human (HEK293, His)

C7/Complement component C7 蛋白, Human (HEK293, His)

目录号: HY-P74371
COA 产品使用指南

C7，也称为补体成分C7蛋白，是膜攻击复合物（MAC）的关键成分，在先天性和适应性免疫反应中发挥关键作用。作为 MAC 的组成部分，C7 积极参与靶细胞质膜孔的形成。C7/Complement component C7 蛋白, Human (HEK293, His) 是重组的 C7/补体成分 C7 蛋白，由 HEK293 表达，带有 C-His 标签。C7/Complement component C7 蛋白, Human (HEK293, His) 全长 843 个氨基酸，分子量为 92-98 kDa。

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描述

C7, also known as complement component C7 protein, is a key component of the membrane attack complex (MAC) and plays a key role in innate and adaptive immune responses. As a component of MAC, C7 actively participates in the formation of target cell plasma membrane pores. C7/Complement component C7 Protein, Human (HEK293, His) is the recombinant human-derived C7/Complement component C7 protein, expressed by HEK293 , with C-His labeled tag. The total length of C7/Complement component C7 Protein, Human (HEK293, His) is 843 a.a., with molecular weight of 92-98 kDa.
研究背景

补体成分 C7 是膜攻击复合物 (MAC) 的组成部分，是先天性和适应性免疫反应的关键效应物。MAC 通过在靶细胞质膜上形成孔，导致细胞裂解和破坏而发挥关键作用。C7 在此过程中充当膜锚，它可以作为单体或二聚体存在，当作为 C5b-7 复合物的一部分时，有可能形成多聚玫瑰花结。MAC 组装从 C5 蛋白水解裂解为 C5a 和 C5b 开始，随后，C5b 依次与 C6、C7、C8 和成孔亚基 C9 的多个拷贝结合。这一精心安排的序列凸显了 C7 在 MAC 组装中的重要作用，有助于免疫系统消除靶细胞的能力。
种属

Human
表达系统

HEK293
标签

C-His
蛋白编号

P10643 (M1-Q843)
基因 ID

730  [NCBI]
蛋白结构
N-term
C7 (M1-Q843)
Accession # P10643
His
C-term
同用名
Complement component C7; C7
分子量

92-98 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
性状

溶液
组分

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
内毒素含量

<1 EU/μg, determined by LAL method.
复溶方法

N/A.
保存条件 & 期限

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

运输条件

Shipping with dry ice.
文件资料

COA (147 KB)

产品使用指南 (1213 KB)

C7/Complement component C7 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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