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  4. CACNA2D1 蛋白, Human (His-SUMO)

CACNA2D1 蛋白, Human (His-SUMO)

目录号: HY-P72109
产品使用指南

CACNA2D1 蛋白，特别是其 α-2/δ 亚基，在调节钙电流密度和电压依赖性钙通道的激活/失活动力学中发挥着关键作用。它有助于兴奋-收缩耦合，协调细胞过程。CACNA2D1 蛋白, Human (His-SUMO) 是重组的 CACNA2D1 蛋白，由 E. coli 表达，带有 N-6*His, N-SUMO 标签。CACNA2D1 蛋白, Human (His-SUMO) 全长 141 个氨基酸，分子量约为 ~32.3 kDa。

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描述

The CACNA2D1 protein, particularly its α-2/δ subunit, plays a key role in regulating calcium current density and activation/deactivation kinetics of voltage-dependent calcium channels. It contributes to excitation-contraction coupling, coordinating cellular processes. CACNA2D1 Protein, Human (His-SUMO) is the recombinant human-derived CACNA2D1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of CACNA2D1 Protein, Human (His-SUMO) is 141 a.a., with molecular weight of ~32.3 kDa.
研究背景

CACNA2D1 蛋白，特别是其 α-2/δ 亚基，在钙电流密度的调节和电压依赖性钙通道的激活/失活动力学中发挥着关键作用。它在兴奋-收缩耦合中发挥着至关重要的作用，有助于细胞过程的协调。α-2/δ亚基通过二硫键与α-2-1和δ-1链形成二聚体，构成电压依赖性钙通道的重要结构成分。这些通道是复杂的多亚基复合物，由 alpha-1 (CACNA1)、alpha-2 (CACNA2D)、beta (CACNB) 和 delta (CACNA2D) 亚基以 1:1:1:1 的比例组成。CACNA2D1 的功能和结构参与强调了其在钙信号传导和细胞反应的精确调节中的重要性。
种属

Human
表达系统

E. coli
标签

N-6*His;N-SUMO
蛋白编号

P54289 (Q528-N668)
基因 ID

781  [NCBI]
蛋白结构
N-term
6*His-SUMO
CACNA2D1 (Q528-N668)
Accession # P54289
C-term
同用名
CA2D1_HUMAN; CACN A2; CACNA2; Cacna2d1; CACNL2A; Calcium channel L type alpha 2 polypeptide; Calcium channel voltage dependent alpha 2/delta subunit 1; CCHL2A; Dihydropyridine receptor alpha 2 subunit; Dihydropyridine sensitive L type calcium channel alpha 2/delta subunit; Dihydropyridine sensitive L type calcium channel subunits alpha 2/delta; L type calcium channel subunit alpha 2; MHS 3; MHS3; Voltage dependent calcium channel subunit alpha 2/delta 1; Voltage gated calcium channel subunit alpha 2/delta 1; Voltage-dependent calcium channel subunit delta-1; Voltage-gated calcium channel subunit alpha-2/delta-1
氨基酸序列

QPKPIGVGIPTINLRKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNFEESGYTFIAPRDYCN

分子量

Approximately 32.3 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CACNA2D1 Protein, Human (His-SUMO) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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