Cadherin-1/CD324 蛋白, Human (HEK293, Fc)

The Cadherin-1/CD324 protein is a calcium-dependent cell adhesion protein that interacts with homology in junctional cells to facilitate cell type sorting. CDH1 is involved in regulating intercellular adhesion, mobility, and epithelial cell proliferation. Cadherin-1/CD324 Protein, Human (HEK293, Fc) is the recombinant human-derived Cadherin-1/CD324 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Cadherin-1/CD324 Protein, Human (HEK293, Fc) is 685 a.a., with molecular weight of 116-126 kDa.

Cadherin-1 (CD324) 是一种钙依赖性细胞粘附蛋白，以其在相邻细胞中与其自身同源相互作用而闻名，从而有助于异质细胞类型的分选。CDH1 是钙粘蛋白家族的成员，在调节细胞间粘附、影响上皮细胞的移动性和增殖方面发挥着至关重要的作用。值得注意的是，CDH1 表现出作为侵入性抑制因子的有效作用，并作为整合素 α-E/β-7E 的配体，影响 Abeta 前体的非淀粉样蛋白降解。此外，CDH1 对 APP C99 和 C83 的产生具有强大的抑制作用，进一步强调了它在细胞过程中的多方面参与及其在病理环境中的潜在影响。

Measured by the ability of the immobilized protein to support the adhesion of MCF-7 human breast adenocarcinoma cells.

Human

HEK293

C-hFc

P12830-1 (Q23-I707)

999  [NCBI]

QEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQI

116-126 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.