2. 重组蛋白
  3. Receptor Proteins
  4. Cell Adhesion Molecules (CAMs)
  5. Cadherins
  6. N-Cadherin
  7. Cadherin-12/CDH12 蛋白, Human (HEK293, His)

Cadherin-12/CDH12 蛋白, Human (HEK293, His)

目录号: HY-P75667
产品使用指南

Cadherin-12/CDH12 是钙粘蛋白家族中的一种钙依赖性细胞粘附蛋白，以其优先的同亲相互作用（连接细胞之间与其自身结合）而闻名。这种相互作用被证明在介导细胞粘附中发挥着至关重要的作用，并且可能在分选异质细胞类型中发挥着关键作用。Cadherin-12/CDH12 蛋白, Human (HEK293, His) 是重组的 Cadherin-12/CDH12 蛋白，由 HEK293 表达，带有 C-His 标签。Cadherin-12/CDH12 蛋白, Human (HEK293, His) 全长 582 个氨基酸，分子量为 80-85 kDa。

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描述

Cadherin-12/CDH12 is a calcium-dependent cell adhesion protein in the cadherin family known for its preferential homophilic interactions (binding to itself between connecting cells). This interaction is shown to play a crucial role in mediating cell adhesion and may play a key role in sorting heterogeneous cell types. Cadherin-12/CDH12 Protein, Human (HEK293, His) is the recombinant human-derived Cadherin-12/CDH12 protein, expressed by HEK293 , with C-His labeled tag. The total length of Cadherin-12/CDH12 Protein, Human (HEK293, His) is 582 a.a., with molecular weight of 80-85 kDa.
研究背景

Cadherin-12/CDH12 蛋白属于钙粘蛋白家族，是一种钙依赖性细胞粘附蛋白。Cadherin-12/CDH12 以其优先的同质相互作用而闻名，在连接细胞之间进行自身结合。这种同质钙粘蛋白相互作用意味着在介导细胞粘附中发挥重要作用，并且可能在分选异质细胞类型的复杂过程中发挥关键作用。通过其钙依赖性粘附特性，Cadherin-12/CDH12 可能有助于细胞之间选择性连接的建立，从而参与细胞相互作用和组织组织的动态调节。
种属

Human
表达系统

HEK293
标签

C-His
蛋白编号

P55289-1/NP_001304156.1 (Q24-A605)
基因 ID

1010
蛋白结构
N-term
CDH12 (Q24-A605)
Accession # P55289
His
C-term
同用名
CDH12; cadherin 12, type 2 (N-cadherin 2); cadherin-12; Br cadherin; CDHB; Br-cadherin; N-cadherin 2; brain cadherin; brain-cadherin; neuronal cadherin 2; neural type cadherin 2; cadherin, neural type, 2; FLJ34857;
分子量

80-85 kDa
纯度

Greater than 80% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Cadherin-12/CDH12 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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