2. 重组蛋白
  3. Receptor Proteins
  4. Cell Adhesion Molecules (CAMs)
  5. Cadherins
  6. K-Cadherin/Cadherin-6
  7. Cadherin-6/KCAD 蛋白, Rat (HEK293, His)

Cadherin-6/KCAD 蛋白, Rat (HEK293, His)

目录号: HY-P77038
产品使用指南

Cadherin-6/KCAD 蛋白是钙依赖性细胞粘附蛋白家族的成员，在介导细胞粘附中发挥着至关重要的作用。它表现出以亲同性方式与相同类型的其他钙粘蛋白分子相互作用的偏好，促进连接细胞之间的粘附。作为一种钙依赖性粘附蛋白，Cadherin-6/KCAD 参与维持组织的结构完整性并调节发育、分化和形态发生等细胞过程。Cadherin-6/KCAD 蛋白, Rat (HEK293, His) 是重组的 Cadherin-6/KCAD 蛋白，由 HEK293 表达，带有 C-His 标签。Cadherin-6/KCAD 蛋白, Rat (HEK293, His) 全长 597 个氨基酸，分子量约为 ~67.9 KDa。

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描述

Cadherin-6/KCAD Protein, a member of the calcium-dependent cell adhesion protein family, assumes a crucial role in mediating cellular adhesion. It exhibits a preference for interacting with other cadherin molecules of the same type in a homophilic manner, facilitating the adhesion between connecting cells. As a calcium-dependent adhesion protein, Cadherin-6/KCAD participates in maintaining the structural integrity of tissues and regulating cellular processes such as development, differentiation, and morphogenesis. Cadherin-6/KCAD Protein, Rat (HEK293, His) is the recombinant rat-derived Cadherin-6/KCAD protein, expressed by HEK293 , with C-His labeled tag. The total length of Cadherin-6/KCAD Protein, Rat (HEK293, His) is 597 a.a., with molecular weight of ~67.9 KDa.
研究背景

Cadherin-6/KCAD 是钙依赖性细胞粘附蛋白家族的成员，在介导细胞粘附中发挥着至关重要的作用。它表现出以亲同性方式与相同类型的其他钙粘蛋白分子相互作用的偏好，促进连接细胞之间的粘附。钙粘蛋白这种选择性地与自身相互作用的独特能力有助于组织和器官中异质细胞类型的分类和组织。作为一种钙依赖性粘附蛋白，Cadherin-6/KCAD 参与维持组织的结构完整性并调节发育、分化和形态发生等细胞过程。Cadherin-6 在正常人肾脏近端肾小管中的特异性表达，并表明 Cadherin-6 表达的改变与肾细胞癌的进展有关。此外，Cadherin-6 在血小板表面表达，并且在体内血栓形成中起着重要作用[1][2]。
种属

Rat
表达系统

HEK293
标签

C-His
蛋白编号

EDL82944 (T19-A615)
基因 ID

/
蛋白结构
N-term
CDH6 (T19-A615)
Accession # EDL82944
His
C-term
同用名
Cadherin-6; Kidney cadherin; K-cadherin; CDH6
分子量

Approximately 67.9 kDa.
纯度

Greater than 80% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Cadherin-6/KCAD Protein, Rat (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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