Calcitonin/CALCA 蛋白, Human (HEK293, His)

Calcitonin Protein, Human (HEK293, His), a recombinant human Calcitonin produced in HEK293 cells, has a His tag at the N-terminus. Calcitonin has an effect on decreasing osteoclast activity and has the potential for hypercalcemia research^[1].

降钙素是一种由 32 个氨基酸组成的激素，由甲状腺 C 细胞分泌。血清钙浓度增加会刺激降钙素分泌，降钙素可防止高钙血症的发生。降钙素也会受到胃泌素等胃肠激素的刺激^[1]。

Human

HEK293

C-6*His

P01258 (A26-N141)

796  [NCBI]

APFRSALESSPADPATLSEDEARLLLAALVQDYVQMKASELEQEQEREGSSLDSPRSKRCGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAPGKKRDMSSDLERDHRPHVSMPQNANHHHHHH

Approximately 16.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Arnold J Felsenfeld, et al. Calcitonin, the forgotten hormone: does it deserve to be forgotten? Clin Kidney J. 2015 Apr;8(2):180-7.  [Content Brief]