2. 重组蛋白
  3. Enzymes & Regulators
  4. Transferases (EC 2)
  5. CAMK1 delta 蛋白, Human (GST)

CAMK1 delta 蛋白, Human (GST)

目录号: HY-P7715
产品使用指南

CAMK1 delta 蛋白, Human (GST)是一种在 E. coli 中表达的，N 末端有 GST 标签的重组人 CAMK1D。CAMK1D 是肿瘤内在免疫抵抗的关键调节剂。

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规格 是否有货
50 μg   询价  
100 μg   询价  

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描述

CAMK1 delta Protein, Human (GST), a recombinant human CAMK1D expressed in E. coli, has a GST tag at the N-terminus. CAMK1D acts as a key modulator of tumor-intrinsic immune resistance[1].
研究背景

钙/钙调蛋白依赖性蛋白激酶 1D (CAMK1D) 在抗 PD-L1/PD-1 治疗难治性癌症类型中与 PD-L1 共表达，并且与这些肿瘤的不良预后相关。CAMK1D 被 CTL 通过 Fas 受体刺激激活，导致 CAMK1D 与 caspase-3、-6 和 -7 结合并磷酸化，抑制其激活和功能[1]。
种属

Human
表达系统

E. coli
标签

N-GST
蛋白编号

Q8IU85 (M1-K385)
基因 ID
蛋白结构
N-term
GST
CAMK1D (M1-K385)
Accession # Q8IU85
C-term
同用名
rHuCAMK1D, N-GST; Calcium/calmodulin-dependent protein kinase type 1D; CaMKI-like protein kinase; CAMK1D;
氨基酸序列

MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPKMARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSSSGVSGVGAERRPRPTTVTAVHSGSK

分子量

60-70 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)
参考文献

CAMK1 delta Protein, Human (GST) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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