CCR4 Protein-VLP, Human (HEK293)

CCR4 protein-VLP is a multifunctional entity that acts as a high-affinity receptor for CC-type chemokines and specifically binds CCL17/TARC, CCL22/MDC, and CKLF1. It mediates chemotactic responses through G(i) protein and activates the phosphatidylinositol-calcium second messenger system. CCR4 Protein-VLP, Human (HEK293) is the recombinant human-derived CCR4 protein, expressed by HEK293, with tag free.Formed in HEK293 cultures, these VLPs concentrate membrane proteins on the cell surface, producing high-concentration proteins ideal for immunization and antibody screening. Given the high immunogenicity of VLPs, the immunization protocol such as antigen dose, schedule, and adjuvant, requires optimization. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

CCR4 蛋白-VLP 是一种多功能实体，作为 CC 型趋化因子的高亲和力受体而脱颖而出，特别表现出对 CCL17/TARC、CCL22/MDC 和 CKLF 亚型 1/CKLF1 的结合亲和力。其功能范围延伸至通过 G(i) 蛋白介导趋化反应，从而激活磷脂酰肌醇-钙第二信使系统。除了作为循环记忆淋巴细胞上的趋化归巢受体的作用之外，CCR4 蛋白-VLP 还可以作为某些原发性 HIV-2 分离株的辅助受体。有趣的是，在中枢神经系统（CNS）中，它有可能介导海马神经元的存活，为其多方面的功能增添了一层复杂性。

Human

HEK293

Tag Free

P51679 (M1-L360)

1233

Full Length

溶液.

Supplied as 0.2 μm filtered solution of PBS, Arginine, pH7.4 with trehalose as protectant.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.