1. 重组蛋白
  2. Immune Checkpoint Proteins CD Antigens Biotinylated Proteins
  3. Inhibitory Checkpoint Molecules NK Cell CD Proteins Macrophage CD Proteins Endothelial cell CD Proteins
  4. CD160
  5. CD160 蛋白, Human (HEK293, His-Avi)

CD160 蛋白, Human (HEK293, His-Avi)

目录号: HY-P78403
产品使用指南

CD160 蛋白存在于免疫细胞上,充当传递刺激或抑制信号的受体,复杂地调节细胞活化和分化。它以 GPI 锚定和跨膜形式存在,可能在 NK 细胞和 T 细胞中启动不同的信号传导途径。作为经典和非经典 MHC I 类分子的受体,它识别 HLA-C,在病毒感染期间触发 NK 细胞的细胞毒性。在 CD8+ T 细胞上,CD160 结合 HLA-A2-B2M,提供共刺激,但可能在慢性病毒感染期间抑制记忆 CD8+ T 细胞中的 TCR 信号传导。CD160 识别内皮细胞上的 HLA-G,控制血管生成。它还参与与 TNFRSF14 的双向细胞间接触信号传导,调节免疫反应,包括抗肿瘤反应和细菌感染。活化的淋巴细胞释放的可溶性 GPI 裂解形式可能会限制淋巴细胞效应器功能。CD160 蛋白, Human (HEK293, His-Avi) 是重组的 CD160 蛋白,由 HEK293 表达,带有 C-Avi, C-His 标签。CD160 蛋白, Human (HEK293, His-Avi) 全长 134 个氨基酸,分子量为 27-33 kDa。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

CD160 Protein, present on immune cells, functions as a receptor delivering stimulatory or inhibitory signals, intricately regulating cell activation and differentiation. Existing in GPI-anchored and transmembrane forms, it likely initiates distinct signaling pathways in NK cells and T cells. Acting as a receptor for classical and non-classical MHC class I molecules, it recognizes HLA-C, triggering NK cell cytotoxicity during viral infections. On CD8+ T cells, CD160 binds HLA-A2-B2M, providing costimulation but may inhibit TCR signaling in memory CD8+ T cells during chronic viral infections. Recognizing HLA-G on endothelial cells, CD160 controls angiogenesis. It also participates in bidirectional cell-cell contact signaling with TNFRSF14, modulating immune responses, including anti-tumor responses and bacterial infections. The soluble GPI-cleaved form released by activated lymphocytes might limit lymphocyte effector functions. CD160 Protein, Human (HEK293, His-Avi) is the recombinant human-derived CD160 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of CD160 Protein, Human (HEK293, His-Avi) is 134 a.a., with molecular weight of 27-33 kDa.

研究背景

CD160 蛋白存在于免疫细胞上,作为一种受体,能够传递刺激或抑制信号,复杂地调节细胞活化和分化。以 GPI 锚定和跨膜形式存在,每种形式都可能通过磷酸肌醇 3-激酶在活化的 NK 细胞中启动不同的信号传导途径,在活化的 T 细胞中通过 LCK 和 CD247/CD3 zeta 链启动不同的信号传导途径。它作为经典和非经典 MHC I 类分子的受体,在急性病毒感染期间识别 HLA-C 并触发 NK 细胞的细胞毒活性,有助于抗病毒先天免疫反应。在 CD8+ T 细胞上,CD160 结合 HLA-A2-B2M,为激活/记忆 T 细胞提供共刺激信号。然而,在持续的抗原刺激过程中,如在慢性病毒感染中观察到的那样,它可能会逐渐抑制记忆 CD8+ T 细胞中的 TCR 信号传导,导致 T 细胞耗竭。在内皮细胞上,CD160 识别 HLA-G,控制免疫特权位点的血管生成。它还充当 TNFRSF14 的受体或配体,参与抗原呈递细胞和淋巴细胞之间的双向细胞间接触信号传导,调节各种情况下的免疫反应,包括抗肿瘤反应和细菌感染。可溶性 GPI 裂解形式通常由活化的淋巴细胞释放,可能通过限制淋巴细胞效应器功能在免疫调节中发挥作用。

种属

Human

表达系统

HEK293

标签

C-Avi;C-His

蛋白编号

O95971 (G25-L158)

基因 ID
蛋白结构
N-term
CD160 (G25-L158)
Accession # O95971
His-Avi
C-term
同用名
CD160;  BY55; BY55FLJ46513; NK1; NK28
分子量

27-33 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
CD160 Protein, Human (HEK293, His-Avi)
目录号:
HY-P78403
需求量: