CD164 蛋白, Cynomolgus (HEK293, Fc)

CD164 Protein, a sialomucin, potentially plays a pivotal role in hematopoiesis, facilitating CD34⁺ cell adhesion while negatively regulating CD34⁺ cell proliferation^[1]. CD164 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived CD164 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD164 Protein, Cynomolgus (HEK293, Fc) is 163 a.a., with molecular weight of 75-110 KDa.

CD164 Protein 属于糖蛋白的粘蛋白或唾液酸粘蛋白家族。它通过 CXCL12/CXCR4 轴调节脐带血 CD133⁺ 细胞迁移，并与前列腺癌转移和骨髓浸润相关。CD164 增强 CXCR4 依赖性细胞运动、成肌细胞迁移和成肌细胞融合成肌管，对肌生成产生积极影响。该蛋白质以同源二聚体（亚型 4）存在，在这些过程中与 CXCR4 相互作用。人 CD164 是一种 1 型整合跨膜分子，其胞外区域包含两个高度 0-糖基化的结构域，通过富含半胱氨酸的非粘蛋白亚结构域连接^[1]。

When Recombinant Cynomolgus CD164 Protein is immobilized at 2 µg/mL (100 µL/well) can bind Anti-CD164 antibody. The ED₅₀ for this effect is 3.053 μg/mL.

Cynomolgus

HEK293

C-hFc

XP_005551610 (N26-D163)

102136974  [NCBI]

NPTPHTNVTSLAPTSNITSAPVTSLPLVTTPAPETCEGRNSCVSCFNASTVNTTCFWIECKDESYCSHNSTVSDCQVGNTTDFCSVVPTATLVPTANSTAKPTVQPSPSTTSKTVTTSGTTNTTVTPTSQPVRKSTFD

Approximately 75-110 kDa to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.