CD1B-B2M Heterodimer 蛋白, Rhesus Macaque (HEK293, His)

CD1B belongs to family 1 of the transmembrane glycoprotein CD1 family and plays a critical role in immune surveillance and response. As a key antigen-presenting molecule, CD1B protein has shown the ability to bind both self and non-self-lipid and glycolipid antigens. CD1B is a potential prognostic biomarker associated with tumor mutation burden and promotes antitumor immunity in lung adenocarcinoma. CD1B-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His) is a recombinant protein dimer complex containing Rhesus Macaque-derived CD1B-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. CD1B-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His), has molecular weight of ~38-45 & 12 KDa.

CD1B 属于跨膜糖蛋白 CD1 家族的第 1 族。CD1 分子在许多不同的人类抗原呈递细胞 (DC、单核胞和某些胸腺细胞) 表面表达。CD1B 蛋白作为一个关键的抗原呈递分子，显示出结合自身和非自身脂质和糖脂抗原的能力，从而促进它们在自然杀伤 T 细胞上向 T 细胞受体呈递。该蛋白与 B2M (β-2 微球蛋白) 形成异二聚体复合物，在免疫监视和应答中起着至关重要的作用。它与皂苷 C 的相互作用进一步增强了其功能库，有助于 T 细胞识别和激活各种抗原的复杂过程。CD1B 是与肿瘤突变负担相关的潜在预后生物标志物，并促进肺腺癌的抗肿瘤免疫。

Measured by its binding ability in a functional ELISA. Immobilized Rhesus Macaque CD1B-B2M Heterodimer at 2 μg/mL (100 μL/well) can bind Anti-CD1B Antibody, The ED₅₀ for this effect is 1.538 μg/mL .

Rhesus Macaque

HEK293

C-6*His

NP_001139006 (E19-S303)&NP_001040602 (I21-M119)

718955  [NCBI]&712428  [NCBI]

Approximately 38-45 & 12 kDa due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.