1. 重组蛋白
  2. CD Antigens
  3. NK Cell CD Proteins Macrophage CD Proteins Erythrocyte CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion-related CD Proteins
  4. LFA-3/CD58
  5. CD2 蛋白, Human (HEK293, Fc)

CD2 蛋白, Human (HEK293, Fc)

目录号: HY-P72886
产品使用指南

CD2 蛋白是一种细胞表面糖蛋白,在 T 细胞激活和粘附中发挥着至关重要的作用。它与其配体 CD58 相互作用,促进免疫反应和细胞间通讯。CD2 蛋白也是免疫疗法的潜在靶标,可能有助于开发免疫相关疾病的新疗法。CD2 蛋白, Human (HEK293, Fc) 是重组的 CD2 蛋白,由 HEK293 表达,带有 C-hFc 标签。CD2 蛋白, Human (HEK293, Fc) 全长 185 个氨基酸,分子量约为 ~48 kDa。

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重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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描述

CD2 Protein, a cell surface glycoprotein, plays a crucial role in T-cell activation and adhesion. It interacts with its ligand, CD58, facilitating immune responses and cell-to-cell communication. CD2 Protein is also a potential target for immunotherapy and may contribute to the development of novel treatments for immune-related disorders. CD2 Protein, Human (HEK293, Fc) is the recombinant human-derived CD2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD2 Protein, Human (HEK293, Fc) is 185 a.a., with molecular weight of ~48 kDa.

研究背景

CD2 蛋白通过与淋巴细胞功能相关抗原 CD58 (LFA-3) 和 CD48/BCM1 相互作用,在介导 T 细胞和其他细胞类型之间的粘附中发挥关键作用。除了其粘附功能外,CD2 还参与触发 T 细胞,其胞质结构域在信号传导中发挥着至关重要的作用。CD2 还与 CD48 和 CD58 (LFA-3) 相互作用,强调了它参与细胞相互作用。此外,CD2 与 CD2AP 和 PSTPIP1 结合,表明其在细胞信号传导途径中的多功能性。值得注意的是,CD2 和 FCGR3A 之间的相互作用调节 NK 细胞活化和细胞毒性,突出了 CD2 在免疫细胞功能中的多种作用。

种属

Human

表达系统

HEK293

标签

C-hFc

蛋白编号

P06729 (K25-D209)

基因 ID

914  [NCBI]

蛋白结构
N-term
CD2 (K25-D209)
Accession # P06729
hFc
C-term
同用名
T-cell surface antigen CD2; LFA-3 receptor; LFA-2; CD2; SRBC
氨基酸序列

MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLD

分子量

Approximately 48 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CD2 Protein, Human (HEK293, Fc)
目录号:
HY-P72886
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