CD20/MS4A1-VLP 蛋白, Mouse (HEK293)

CD20/MS4A1 protein regulates cellular calcium influx, essential for B-lymphocyte development, differentiation, and activation. It activates store-operated calcium channels, allowing calcium influx through B-cell receptor/BCR activation. CD20/MS4A1 protein forms homotetramers and interacts with cell surface IgM chains, the antigen-binding parts of the BCR. CD20/MS4A1-VLP Protein, Mouse (HEK293) is the recombinant mouse-derived CD20/MS4A1-VLP protein, expressed by HEK293, with tag free.Formed in HEK293 cultures, these VLPs concentrate membrane proteins on the cell surface, producing high-concentration proteins ideal for immunization and antibody screening. Given the high immunogenicity of VLPs, the immunization protocol such as antigen dose, schedule, and adjuvant, requires optimization. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

CD20/MS4A1 蛋白是一种 B 淋巴细胞特异性膜蛋白，在调节细胞钙内流方面发挥着至关重要的作用，这对于 B 淋巴细胞的发育、分化和激活是必需的。它作为钙库操纵 (SOC) 通道的一个组成部分发挥作用，在 B 细胞受体/BCR 激活后促进钙流入。CD20/MS4A1 蛋白形成同源四聚体，并与细胞表面 IgM 的重链和轻链相互作用，IgM 是 BCR 的抗原结合成分。

Mouse

HEK293

Tag Free

P19437 (M1-P291)

12482

Full Length

溶液.

Supplied as 0.2 μm filtered solution of PBS, Arginine, pH7.4 with trehalose as protectant. Due to the cytotoxicity of the detergent, this product is not appropriate for cell - based experiments.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.