CD200R1 蛋白, Human (Biotinylated, HEK293, Fc-Avi)

CD200R1 protein is an inhibitory receptor that regulates key interactions by binding to the CD200/OX2 glycoprotein, thereby limiting inflammation by inhibiting TNF-α, interferons, and iNOS. CD200R1 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived CD200R1 protein, expressed by HEK293, with C-Avi, C-hFc labeled tag. The total length of CD200R1 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 240 a.a., with molecular weight of 70-115 kDa.

CD200R1 是一种抑制性受体，通过与 CD200/OX2 细胞表面糖蛋白结合而充当关键调节剂。其调节作用延伸到通过抑制促炎分子（包括 TNF-α、干扰素和诱导型一氧化氮合酶 (iNOS)）来限制炎症，以响应特定的刺激。有趣的是，CD200R1 在与人疱疹病毒 8 K14 病毒 CD200 同源物结合时表现出相当的亲和力和动力学，反映了其与宿主 CD200 的相互作用。CD200 和 CD200R1 之间的相互作用是通过它们各自的 N 端 Ig 样结构域促进的。此外，CD200R1 与人类疱疹病毒 8 vOX2 蛋白结合，进一步扩展其在细胞过程中的多功能相互作用。

Immobilized Human CD200 Fc at 2 μg/mL (100 μL/well) can bind Biotinylated Human CD200 R1 Fc-Avi with a linear range of 0.5-7.8 ng/mL.

Human

HEK293

C-Avi;C-hFc

AAQ19772 (A27-L266)

131450  [NCBI]

70-115 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized a 0.22 μm filtered solution of Tris with Glycine, Arginine and NaCl, pH 7.5. Normally trehalose is added as protectant before lyophilization.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.