1. 重组蛋白
  2. Immune Checkpoint Proteins Receptor Proteins
  3. Stimulatory Immune Checkpoint Molecules
  4. CD200R
  5. CD200R1
  6. CD200R1 蛋白, Mouse (HEK293, His)

CD200R1 蛋白, Mouse (HEK293, His)

目录号: HY-P75625
COA 产品使用指南

CD200R1 蛋白通过与 CD200/OX2 细胞表面糖蛋白结合并抑制促炎分子表达来抑制炎症反应。CD200R1 通过其 N 端 Ig 样结构域与 CD200 相互作用,为其调节炎症的作用提供了分子机制。CD200R1 蛋白, Mouse (HEK293, His) 是重组的 CD200R1 蛋白,由 HEK293 表达,带有 C-His, C-6*His 标签。CD200R1 蛋白, Mouse (HEK293, His) 全长 213 个氨基酸,分子量为 55-65 kDa。

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规格 价格 是否有货 数量
Free Sample   Apply now  
5 μg ¥470 In-stock
10 μg ¥800 In-stock
50 μg ¥2240 In-stock
100 μg ¥3800 In-stock
500 μg ¥9880 In-stock
> 100 μg   询价  

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描述

CD200R1 protein inhibits inflammatory responses by binding to CD200/OX2 cell surface glycoprotein and suppressing pro-inflammatory molecule expression. CD200R1 interacts with CD200 through their N-terminal Ig-like domains, providing a molecular mechanism for its role in regulating inflammation. CD200R1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD200R1 protein, expressed by HEK293 , with C-His, C-6*His labeled tag. The total length of CD200R1 Protein, Mouse (HEK293, His) is 213 a.a., with molecular weight of 55-65 kDa.

研究背景

CD200R1 蛋白作为 CD200/OX2 细胞表面糖蛋白的抑制性受体,在调节炎症反应中发挥关键作用。其抑制作用表现为响应特定刺激而抑制促炎分子的表达,例如 TNF-α、干扰素和诱导型一氧化氮合酶 (iNOS)。CD200CD200R1 之间的相互作用是通过它们各自的 N 端 Ig 样结构域介导的,突显了该受体有助于调节炎症过程的关键分子机制。

生物活性

Measured by its binding ability in a functional ELISA. Immobilized Mouse CD200, at 2 μg/mL (100 μL/well) can bind Biotinylated Mouse CD200R1 protein. The ED50 for this effect is 57.28 ng/mL.

  • Measured by its binding ability in a functional ELISA. Immobilized Mouse CD200, at 2 μg/mL (100 μL/well) can bind Biotinylated Mouse CD200R1 protein. The ED50 for this effect is 57.28 ng/mL。
种属

Mouse

表达系统

HEK293

标签

C-His;C-6*His

蛋白编号

Q9ES57/NP_067300.1 (T26-P238)

基因 ID

57781  [NCBI]

蛋白结构
N-term
CD200R1 (T26-P238)
Accession # Q9ES57/NP_067300.1
His
C-term
同用名
Cell surface glycoprotein CD200 receptor 1; CD200R; CRTR2; MOX2R; OX2R
氨基酸序列

TDKNQTTQNNSSSPLTQVNTTVSVQIGTKALLCCFSIPLTKAVLITWIIKLRGLPSCTIAYKVDTKTNETSCLGRNITWASTPDHSPELQISAVTLQHEGTYTCETVTPEGNFEKNYDLQVLVPPEVTYFPEKNRSAVCEAMAGKPAAQISWSPDGDCVTTSESHSNGTVTVRSTCHWEQNNVSDVSCIVSHLTGNQSLSIELSRGGNQSLRP

分子量

55-65 kDa

纯度
  • Greater than 95% as determined by reducing SDS-PAGE.The protein migrates as a 55-65 kDa band under reducing SDS-PAGE due to glycosylation.
性状

无菌粉末

组分

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CD200R1 Protein, Mouse (HEK293, His)
目录号:
HY-P75625
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