CD229/SLAMF3 蛋白, Human (Biotinylated, HEK293, His-Avi)

CD229/SLAMF3 Protein, a self-ligand receptor in the SLAM family, modulates immune cell activation and differentiation through cell interactions. Crucial for innate and adaptive immune responses, its activities are controlled by SH2D1A/SAP and/or SH2D1B/EAT-2. It mediates T-cell adhesion, promotes Th17 differentiation with IL-17 secretion requiring SH2D1A, and facilitates RORC recruitment to the IL-17 promoter. CD229/SLAMF3 acts as a negative immune regulator, inhibiting autoantibody responses and CD4(+) T-cell IFN-gamma secretion. It regulates thymic innate CD8(+) T-cell size and iNKT cell development, interacting with SH2D1A, SH2D1B, INPP5D, and PTPN11, blocking PTPN11 interaction with SH2D1A. CD229/SLAMF3 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD229/SLAMF3 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of CD229/SLAMF3 Protein, Human (Biotinylated, HEK293, His-Avi) is 407 a.a., with molecular weight of 70-80 kDa.

CD229/SLAMF3 蛋白是一种自身配体受体，属于信号淋巴细胞激活分子 (SLAM) 家族。它通过同型或异型细胞间相互作用充当免疫细胞激活和分化的调节剂。该受体在调节先天性和适应性免疫反应中发挥着至关重要的作用。小细胞质接头蛋白 SH2D1A/SAP 和/或 SH2D1B/EAT-2 的存在或不存在控制其活性。CD229/SLAMF3 通过同源相互作用参与 T 淋巴细胞和辅助细胞之间的粘附反应。它促进 T 细胞分化为辅助 T 细胞 Th17 表型，导致 IL-17 分泌增加，共刺激活性需要 SH2D1A。此外，它还促进 RORC 招募至 IL-17 启动子。CD229/SLAMF3 还可能充当免疫反应的负调节因子，有助于维持外周细胞耐受性。它可以抑制自身抗体反应和CD4(+) T细胞分泌IFN-γ。此外，它还参与调节胸腺先天性 CD8(+) T 细胞的大小和恒定自然杀伤 T (iNKT) 细胞的发育。CD229/SLAMF3 与 SH2D1A、SH2D1B、INPP5D 和 PTPN11 相互作用，与 PTPN11 的相互作用被 SH2D1A 阻断。

Human

HEK293

C-Avi;C-His

Q9HBG7-1 (K48-K454)

4063  [NCBI]

70-80 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.