CD23/Fc epsilon RII 蛋白, Human (HEK293, His)

CD23 or Fc epsilon receptor II (Fc epsilon RII) is a low-affinity receptor for immunoglobulin E (IgE) and complements receptor 2 (CR2/CD21). CD23 is present on B cells, regulates IgE production and B cell differentiation, and aids in IgE-dependent antigen uptake. CD23/Fc epsilon RII Protein, Human (HEK293, His) is the recombinant human-derived CD23/Fc epsilon RII protein, expressed by HEK293 , with N-8*His labeled tag. The total length of CD23/Fc epsilon RII Protein, Human (HEK293, His) is 274 a.a., with molecular weight of 35-40 kDa.

CD23，也称为 Fc epsilon 受体 II (Fc epsilon RII)，作为免疫球蛋白 E (IgE) 的低亲和力受体发挥作用，并补充受体 2 (CR2/CD21)。B 细胞上的 CD23 在 IgE 产生和 B 细胞分化的调节中发挥着至关重要的作用，可促进 IgE 依赖性抗原的摄取和呈递给 T 细胞。在巨噬细胞中，IgE 结合和抗原交联通过激活 L-精氨酸-一氧化氮途径触发细胞内杀死寄生虫。CD23 形成同源三聚体并与 IGHE 相互作用，特别是通过其 C 型凝集素结构域，调节 IgE 稳态。此外，CD23 通过其 C 末端与 CR2/CD21 相互作用，特别是与 CR2/CD21 的 Sushi 结构域 1 和 2 结合。这些相互作用强调了 CD23 在免疫反应中的多方面参与，从 B 细胞激活到巨噬细胞介导的针对寄生虫的防御。

Human

HEK293

N-8*His

P06734 (D48-S321)

2208  [NCBI]

DTTQSLKQLEERAARNVSQVSKNLESHHGDQMAQKSQSTQISQELEELRAEQQRLKSQDLELSWNLNGLQADLSSFKSQELNERNEASDLLERLREEVTKLRMELQVSSGFVCNTCPEKWINFQRKCYYFGKGTKQWVHARYACDDMEGQLVSIHSPEEQDFLTKHASHTGSWIGLRNLDLKGEFIWVDGSHVDYSNWAPGEPTSRSQGEDCVMMRGSGRWNDAFCDRKLGAWVCDRLATCTPPASEGSAESMGPDSRPDPDGRLPTPSAPLHS

35-40 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.