1. 重组蛋白
  2. CD Antigens Enzymes & Regulators
  3. T Cell CD Proteins Macrophage CD Proteins Stem Cell CD Proteins Epithelial cell CD Proteins Hydrolases (EC 3)
  4. DPP IV/CD26
  5. CD26/Dipeptidyl Peptidase 4 蛋白, Human (HEK293, Fc)

CD26/Dipeptidyl Peptidase 4 蛋白, Human (HEK293, Fc)

目录号: HY-P72976
COA 产品使用指南

CD26/二肽基肽酶 4 蛋白是一种细胞表面糖蛋白受体,可诱导 T 细胞增殖和 NF-κ-B 激活。CD26 还与 FAP 一起促进细胞周蛋白水解、内皮细胞迁移和细胞外基质的侵袭。CD26/Dipeptidyl Peptidase 4 蛋白, Human (HEK293, Fc) 是重组的 CD26/二肽基肽酶 4 蛋白,由 HEK293 表达,带有 N-hFc 标签。CD26/Dipeptidyl Peptidase 4 蛋白, Human (HEK293, Fc) 全长 738 个氨基酸,分子量为 120-130 kDa。

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50 μg ¥4200 In-stock
100 μg   询价  

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描述

The CD26/dipeptidyl peptidase 4 protein is a cell surface glycoprotein receptor that induces T cell proliferation and NF-kappa-B activation. CD26 also works with FAP to promote pericellular proteolysis, endothelial cell migration, and invasion of the extracellular matrix. CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293, Fc) is the recombinant human-derived CD26/Dipeptidyl Peptidase 4 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293, Fc) is 738 a.a., with molecular weight of 120-130 kDa.

研究背景

CD26/二肽基肽酶 4 蛋白是一种细胞表面糖蛋白受体,在 T 细胞受体 (TCR) 介导的 T 细胞激活所必需的共刺激信号中发挥着关键作用。作为 T 细胞共激活的正调节因子,CD26 与 ADA、CAV1、IGF2R 和 PTPRC 相互作用,以 T 细胞受体/CD3 依赖性方式导致 T 细胞增殖和 NF-κ-B 激活。它与 CAV1 和 CARD11 的结合诱导 T 细胞增殖,而它与 ADA 的相互作用则调节淋巴细胞-上皮细胞粘附。CD26 与 FAP 相关,参与细胞外基质的细胞周蛋白水解,有助于内皮细胞的迁移和侵袭。此外,它可能在促进淋巴管内皮细胞粘附、迁移和管形成方面发挥作用。CD26 作为具有二肽基肽酶活性的丝氨酸外肽酶,通过切割循环中的肽来调节各种生理过程,包括趋化因子、促有丝分裂生长因子、神经肽和肽激素。值得注意的是,CD26 在微生物感染过程中充当人类冠状病毒 MERS-CoV-2 的受体。

生物活性

Measured by its ability to bind Cynomolgus CXCL12 in a functional ELISA. Loaded CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293, Fc) on ProA Biosensor, can bind MERS-CoV Spike/RBD Protein fragment (RBD, aa 367-606, His ) with an affinity constant of 1.04 nM.

种属

Human

表达系统

HEK293

标签

N-hFc

蛋白编号

P27487 (N29-P766)

基因 ID
蛋白结构
N-term
hFc
CD26 (N29-P766)
Accession # P27487
C-term
同用名
Dipeptidyl peptidase 4; ADABP; ADCP-2; DPP IV; TP103; CD26; DPP4
氨基酸序列

NKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP

分子量

120-130 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293, Fc)
目录号:
HY-P72976
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