2. 重组蛋白
  3. Immune Checkpoint Proteins CAR-T related Proteins CD Antigens
  4. Inhibitory Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins
  5. B7-H3 B7-H3/CD276
  6. CD276/B7-H3 蛋白, Rat (HEK293, Fc)

CD276/B7-H3 蛋白, Rat (HEK293, Fc)

目录号: HY-P74315
产品使用指南

CD276/B7-H3 蛋白调节 T 细胞介导的免疫反应和移植排斥。它还促进骨形成，在骨免疫界面发挥作用。此外，它还能激活针对肿瘤的免疫反应，通过自然杀伤细胞和 CD8 T 细胞消除肿瘤。它与 TREML2 的相互作用增强了 T 细胞的激活，突出了它在免疫调节中的作用。CD276/B7-H3 蛋白, Rat (HEK293, Fc) 是重组的 CD276/B7-H3 蛋白，由 HEK293 表达，带有 C-hFc 标签。CD276/B7-H3 蛋白, Rat (HEK293, Fc) 全长 244 个氨基酸，分子量约为 ~61 kDa。

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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描述

CD276/B7-H3 Protein regulates T-cell-mediated immune responses and transplant rejection. It also promotes bone formation, functioning at the bone-immune interface. Additionally, it activates immune responses against tumors, eliminating them through natural killer cells and CD8 T-cells. Its interaction with TREML2 enhances T-cell activation, highlighting its role in immune regulation. CD276/B7-H3 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD276/B7-H3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD276/B7-H3 Protein, Rat (HEK293, Fc) is 244 a.a., with molecular weight of ~61 kDa.
研究背景

CD276/B7-H3 是一种多方面的蛋白质，对 T 细胞介导的免疫反应以及急性和慢性移植排斥的进展发挥调节影响。除了其免疫调节作用外，它还可能对骨形成做出积极贡献，表现出骨-免疫界面的双重功能。此外，CD276 通过激活获得性和先天性免疫反应，成为抗肿瘤免疫的关键参与者，从而通过自然杀伤细胞和 CD8 T 细胞依赖性机制消除肿瘤细胞。值得注意的是，它与 TREML2 的相互作用增强了 T 细胞的激活，进一步强调了它在免疫调节中的复杂参与。
种属

Rat
表达系统

HEK293
标签

C-hFc
蛋白编号

Q7TPB4 (M1-F244)
基因 ID

315716  [NCBI]
蛋白结构
N-term
CD276 (M1-F244)
Accession # Q7TPB4
hFc
C-term
同用名
B7H3; B7-H3B7 homolog 3; CD276; Costimulatory molecule
分子量

Approximately 61 kDa
纯度

Greater than 85% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CD276/B7-H3 Protein, Rat (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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