CD30/TNFRSF8 蛋白, Human (HEK293, His)

CD30/TNFRSF8, a receptor for TNFSF8/CD30L, regulates cellular growth and lymphoblast transformation. It activates NF-kappa-B, modulating gene expression. Interactions with TRAF1, TRAF2, TRAF3, and TRAF5 indicate involvement in complex signaling networks. Engagement with TNFSF8 implies impact on immune responses and cellular homeostasis, emphasizing its significance in fundamental biological processes. CD30/TNFRSF8 Protein, Human (HEK293, His) is the recombinant human-derived CD30/TNFRSF8 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD30/TNFRSF8 Protein, Human (HEK293, His) is 361 a.a., with molecular weight of 60-95 kDa.

CD30/TNFRSF8 是 TNFSF8/CD30L 的受体，参与细胞生长的调节和活化的淋巴母细胞的转化。该受体通过激活 NF-kappa-B（与多种细胞过程相关的关键转录因子）在调节基因表达中发挥作用。CD30/TNFRSF8 与 TRAF1、TRAF2、TRAF3 和 TRAF5 等信号传导接头的相互作用强调了其参与复杂的细胞信号传导网络。该受体与 TNFSF8 的结合表明其对免疫反应和细胞稳态的潜在影响，突出了其在调节基本生物过程中的重要性。

Human

HEK293

C-6*His

P28908 (F19-K379)

943  [NCBI]

FPQDRPFEDTCHGNPSHYYDKAVRRCCYRCPMGLFPTQQCPQRPTDCRKQCEPDYYLDEADRCTACVTCSRDDLVEKTPCAWNSSRVCECRPGMFCSTSAVNSCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPGVSPACASPENCKEPSSGTIPQAKPTPVSPATSSASTMPVRGGTRLAQEAASKLTRAPDSPSSVGRPSSDPGLSPTQPCPEGSGDCRKQCEPDYYLDEAGRCTACVSCSRDDLVEKTPCAWNSSRTCECRPGMICATSATNSCARCVPYPICAAETVTKPQDMAEKDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQASKTLPIPTSAPVALSSTGK

60-95 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 7.5.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.