1. 重组蛋白
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  3. Macrophage CD Proteins Monocyte CD Proteins Stem Cell CD Proteins Platelet CD Proteins Erythrocyte CD Proteins Dendritic Cell CD Proteins Endothelial cell CD Proteins
  4. SR-BI/CD36 TREM-1/CD354
  5. CD36 蛋白, Rat (HEK293, His)

CD36 蛋白, Rat (HEK293, His)

目录号: HY-P74302
COA 产品使用指南

CD36 是一种多功能糖蛋白,可作为多种配体的受体,包括血小板反应蛋白、胶原蛋白和氧化低密度脂蛋白。其多价配体诱导 CD36 簇,启动信号转导。CD36 蛋白, Rat (HEK293, His) 是重组的 CD36 蛋白,由 HEK293 表达,带有 C-His 标签。CD36 蛋白, Rat (HEK293, His) 全长 410 个氨基酸,分子量为 70-80 kDa。

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10 μg ¥840 In-stock
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100 μg ¥4000 In-stock
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描述

CD36 is a multifunctional glycoprotein that serves as a receptor for a variety of ligands, including thrombospondin, collagen, and oxidized low-density lipoprotein. Its multivalent ligand induces CD36 clusters, initiating signal transduction. CD36 Protein, Rat (HEK293, His) is the recombinant rat-derived CD36 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD36 Protein, Rat (HEK293, His) is 410 a.a., with molecular weight of 70-80 kDa.

研究背景

CD36 是一种多功能糖蛋白,作为多种配体的受体,包括血小板反应蛋白、纤连蛋白、胶原蛋白或淀粉样蛋白等蛋白质实体,以及氧化低密度脂蛋白 (oxLDL)、阴离子磷脂、长链磷脂等脂质成分。链脂肪酸和细菌二酰化脂肽。由于其多价性质,这些配体可以同时与多个受体结合,促进 CD36 簇的形成,从而启动信号转导和受体-配体复合物的内化。随后的细胞反应在血管生成、炎症反应、脂肪酸代谢以及肠道中味觉和膳食脂肪的处理中发挥着关键作用。CD36 参与结合长链脂肪酸,促进其转运到细胞中,有助于肌肉脂质利用、脂肪能量储存和肠道脂肪吸收。从机制上讲,脂肪酸结合激活下游激酶 LYN,导致棕榈酰转移酶 ZDHHC5 磷酸化和失活,随后导致 CD36 去棕榈酰化和小凹胞吞作用。在小肠中,CD36 可能通过激活 MAPK1/3 (ERK1/2) 信号通路参与膳食脂肪酸和胆固醇的近端吸收。此外,CD36 对于口腔脂肪感知和偏好至关重要,它存在于味觉受体细胞中,介导细胞内钙水平增加并激活味觉神经元。在下丘脑腹内侧区,CD36 在感知长链脂肪酸以及调节能量和葡萄糖稳态方面发挥着关键作用。CD36 作为血小板反应蛋白的受体和 TLR4:TLR6 异二聚体的辅助受体,分别促进单核细胞/巨噬细胞的抗血管生成作用和炎症。配体结合后,CD36 与 TLR4:TLR6 异二聚体相互作用,导致内化并通过 NF-κ-B 依赖性途径引发炎症反应。此外,CD36 作为微生物二酰化脂肽的选择性和非冗余传感器,引发 NF-κ-B 依赖性细胞因子的产生,并随后通过 TLR2:TLR6 异二聚体信号传导靶向脂筏依赖性途径中的高尔基体。

生物活性

Immobilized Rat CD36, His Tag at 0.5 μg/mL (100 μl/well) on the plate. Dose response curve for Anti-CD36 Antibody, Rabbit IgG Tag with the EC50 of 7.9 ng/mL determined by ELISA.

种属

Rat

表达系统

HEK293

标签

C-His

蛋白编号

Q07969 (G30-K439)

基因 ID

29184  [NCBI]

蛋白结构
N-term
CD36 (G30-K439)
Accession # Q07969
His
C-term
同用名
Platelet glycoprotein 4; GPIIIB; GPIV; CD36; Fat
氨基酸序列

GDLLIEKTIKREVVLEEGTIAFKNWVKTGTTVYRQFWIFDVQNPEEVAKNSSKIKVKQRGPYTYRVRYLAKENITQDPKDSTVSFVQPNGAIFEPSLSVGTENDNFTVLNLAVAAAPHIYTNSFVQGVLNSLIKKSKSSMFQTRSLKELLWGYKDPFLSLVPYPISTTVGVFYPYNNTVDGVYKVFNGKDNISKVAIIDTYKGKRNLSYWESYCDMINGTDAASFPPFVEKSQTLRFFSSDICRSIYAVFESEVNLKGIPVYRFVLPANAFASPLQNPDNHCFCTEKVISNNCTSYGVLDIGKCKEGKPVYISLPHFLHASPDVSEPIEGLNPNEDEHRTYLDVEPITGFTLQFAKRLQVNILVKPARKIEALKNLKRPYIVPILWLNETGTIGDEKAEMFRNQVTGKIK

分子量

70-80 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CD36 Protein, Rat (HEK293, His)
目录号:
HY-P74302
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