1. 重组蛋白
  2. CD Antigens
  3. Platelet CD Proteins
  4. CD42c/GP-Ib beta
  5. CD42c 蛋白, Rat (HEK293, Fc)

CD42c 蛋白, Rat (HEK293, Fc)

目录号: HY-P77323
产品使用指南

CD42c 蛋白是一种血小板表面膜蛋白,可通过与内皮下组织中的冯维勒布兰德因子 (vWF) 结合来主动组装栓塞。GP-Ib 异二聚体由二硫键连接的 GP-Ib β 亚基和一个 GP-Ib α 亚基形成,构成该蛋白质复合物。CD42c 蛋白, Rat (HEK293, Fc) 是重组的 CD42c 蛋白,由 HEK293 表达,带有 C-hFc 标签。CD42c 蛋白, Rat (HEK293, Fc) 全长 147 个氨基酸,分子量约为 ~63 kDa。

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     可免费申领三个不同产品的试用装。

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描述

The CD42c protein is a platelet surface membrane protein that actively assembles plugs by binding to von Willebrand factor (vWF) in the subendothelium. The GP-Ib heterodimer is formed from the disulfide-linked GP-Ib β subunit and one GP-Ib α subunit, which constitute this protein complex. CD42c Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD42c protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD42c Protein, Rat (HEK293, Fc) is 147 a.a., with molecular weight of ~63 kDa.

研究背景

CD42c 是血小板上的一种表面膜蛋白,通过与预先结合在内皮下的血管性血友病因子 (vWF) 结合,积极促进血小板栓塞的组装。该蛋白质复合物包含两个通过二硫键连接到一个 GP-Ib α 亚基的 GP-Ib β 亚基,形成 GP-Ib 异二聚体。此外,GP-IX 通过非共价连接与 GP-Ib 异二聚体错综复杂地结合,增强了该血小板表面受体的结构完整性和功能性。在分子相互作用中,CD42c 与肿瘤坏死因子受体相关因子 4 (TRAF4) 的关联相似,有助于调控血小板功能的调节网络。

种属

Rat

表达系统

HEK293

标签

C-hFc

蛋白编号

Q9JJM7 (M1-C147)

基因 ID

116727  [NCBI]

蛋白结构
N-term
CD42c (M1-C147)
Accession # Q9JJM7
hFc
C-term
同用名
Platelet glycoprotein Ib beta chain; GP-Ib beta; GP1BB
分子量

Approximately 63 kDa

纯度

Greater than 85% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

CD42c Protein, Rat (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CD42c Protein, Rat (HEK293, Fc)
目录号:
HY-P77323
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