1. 重组蛋白
  2. CAR-T related Proteins CD Antigens
  3. CD7 NK Cell CD Proteins Macrophage CD Proteins
  4. CD7 蛋白, Rat (HEK293, Fc)

CD7 蛋白, Rat (HEK293, Fc)

目录号: HY-P74273
产品使用指南

CD7 蛋白是一种在胸腺细胞和成熟的 T 细胞中表达的免疫球蛋白超家族成员。CD7 Protein可激活 PI3K 信号通路参与 T 和 NK 细胞的活化。CD7 Protein是治疗 T 细胞急性淋巴细胞白血病 (T-ALL) 和 T-淋巴瘤的关键因子。CD7 蛋白, Rat (HEK293, Fc) 是重组的 CD7 蛋白,由 HEK293 表达,带有 C-hFc 标签。CD7 蛋白, Rat (HEK293, Fc) 全长 149 个氨基酸,分子量约为 45-60 kDa。

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5 μg ¥580 In-stock
10 μg ¥950 In-stock
50 μg ¥2400 In-stock
100 μg   询价  

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描述

The CD7 Protein is a member of the immunoglobulin superfamily expressed in thymocytes and mature T cells. CD7 Protein can activate the PI3K signaling pathway involved in the activation of T and NK cells. CD7 Protein is a key factor in the treatment of T-cell acute lymphoblastic leukemia (T-ALL) and T-lymphoma. CD7 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD7 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD7 Protein, Rat (HEK293, Fc) is 149 a.a., with molecular weight of 45-60 kDa.

研究背景

CD7 蛋白是免疫球蛋白超家族的一种跨膜蛋白,存在于胸腺细胞和成熟的 T 细胞中。在早期淋巴细胞发育过程中,它在 T 细胞相互作用和 T 细胞/ B 细胞相互作用中起重要作用。CD7 可激活 PI3K 信号通路参与 T 和 NK 细胞的活化。CD7 广泛分布于肿瘤,被认为是治疗 T 细胞急性淋巴细胞白血病 (T-ALL) 和 T-淋巴瘤的关键因子。

生物活性

Measured by its binding ability in a functional ELISA. Immobilized Rat CD7, at 0.5μg/mL (100μL/well) can bind Anti-CD7 antibody. The ED50 for this effect is 2.645μg /mL.

种属

Rat

表达系统

HEK293

标签

C-hFc

蛋白编号

B2RZ54 (Q23-P149)

基因 ID

303747  [NCBI]

蛋白结构
N-term
CD7 (M1-P149)
Accession # B2RZ54
hFc
C-term
同用名
CD7; LEU-9; T-cell antigen CD7
氨基酸序列

QEVHQSPRVVIASEGESINITCSTRGDLEGLIMKRIWPQASNVIYFEDELEPTVDSAFSGRINFSGSQKNLTIIMSLLQEADTGAYTCEAVRKVSVHGLFTTVVVKEKLSHEAYRSQEPLQTSVSLP

分子量

Approximately 45-60 kDa due to the glycosylation.

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CD7 Protein, Rat (HEK293, Fc)
目录号:
HY-P74273
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