CD79B 蛋白, Rhesus Macaque (HEK293, His)

CD79B protein binds to CD79A and initiates the B cell antigen receptor complex (BCR) signaling cascade. This results in complex internalization, transport to late endosomes and antigen presentation. CD79B Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived CD79B protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD79B Protein, Rhesus Macaque (HEK293, His) is 132 a.a., with molecular weight of 20-30 kDa.

CD79B 蛋白与 CD79A 一起在启动 B 细胞抗原受体复合物 (BCR) 触发的信号转导级联中发挥重要作用。这一关键功能导致复合物的内化，随后运输至晚期内体，以及最终的抗原呈递。CD79B 可能通过招募磷酸化 CD79A 的激酶或通过接合与 CD79A 结合的蛋白质来增强 CD79A 的磷酸化，从而保护其免于去磷酸化。CD79B 与 α 链形成异二聚体，形成二硫键连接的复合物。它是 B 细胞抗原受体复合物的组成部分，其中 α/β 链异二聚体与包含两条重链和两条轻链的抗原特异性膜结合表面免疫球蛋白非共价结合。此外，CD79B 与 LYN 相互作用，进一步促进其在 B 细胞信号传导中的调节作用。

Rhesus Macaque

HEK293

C-6*His

H9ZFT8 (A30-D161)

718218  [NCBI]

AKSEDLYPNPKGSACSRIWQSPRFIARKRGFTVKMHCYVTNSTFSIVSWLRKRETDKEPQQVNLEQGHMHQTQNSSVTTLIIQDIRFEDNGIYFCQQECSKTSEVYRGCGTELRVMGFSTLAQLKQRNTLKD

20-30 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.