CD81 Protein-VLP, Human (HEK293)

The CD19 receptor is critical for B cell activation, driving the trafficking and assembly of CD19-CR2 and BCR complexes, thereby lowering the antigenic threshold for B cell clonal expansion. In T cells, CD19 contributes to CD3 localization and influences polarization. CD81 Protein-VLP, Human (HEK293) is the recombinant human-derived CD81 protein, expressed by HEK293, with tag free.Formed in HEK293 cultures, these VLPs concentrate membrane proteins on the cell surface, producing high-concentration proteins ideal for immunization and antibody screening. Given the high immunogenicity of VLPs, the immunization protocol such as antigen dose, schedule, and adjuvant, requires optimization. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

CD19 受体在活化 B 细胞的运输和区室化中发挥着至关重要的作用。它允许 CD19-CR2/CD21 和 B 细胞受体 (BCR) 复合物在信号传导 TERM 处组装，从而导致触发 B 细胞克隆扩增和抗体产生所需的抗原阈值剂量较低。该受体还促进 CD247/CD3 zeta 与 T 细胞中的 B 细胞在抗原诱导的突触处的定位，提供向 2 型辅助 T 表型的共刺激和极化。此外，CD19 存在于 MHC II 类区室中，可能在抗原呈递中发挥作用。它可以充当细胞-细胞融合过程的正调节剂和负调节剂。CD19正向调节精卵融合并可能参与顶体反应。在成肌细胞中，它与 CD9 和 PTGFRN 结合，抑制肌肉再生过程中的肌管融合。在巨噬细胞中，CD19 与 CD9 以及 beta-1 和 beta-2 整合素结合，以防止巨噬细胞融合成专门摄取补体调理的大颗粒的多核巨细胞。它还可以防止单核细胞祖细胞融合成负责骨吸收的破骨细胞。CD19 还可以调节酶活性的区室化。在 T 细胞中，它定义 dNTPase SAMHD1 的亚细胞定位，并允许其被蛋白酶体降解，从而控制细胞内 dNTP 水平。CD19 还参与细胞粘附和运动，积极调节整合素介导的巨噬细胞粘附，特别是在肺部炎症反应中。此外，CD19 在肝细胞中充当丙型肝炎病毒 (HCV) 的受体，与 CLDN1 和 CLDN1-CD81 受体复合物结合，对于 HCV 进入宿主细胞至关重要。

Human

HEK293

Tag Free

P60033 (G2-Y263)

975

Full Length

溶液.

Supplied as 0.2 μm filtered solution of PBS, Arginine, pH7.4 with trehalose as protectant.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.