2. 重组蛋白
  3. Enzymes & Regulators
  4. Transferases (EC 2) Serine/Threonine Kinase Proteins
  5. Cyclin-Dependent Kinases (CDKs)
  6. CDK15-CCNY Heterodimer 蛋白, Human (Sf9)

CDK15-CCNY Heterodimer 蛋白, Human (Sf9)

目录号: HY-P701362
产品使用指南

CDK15ic 蛋白作为抗凋亡激酶发挥作用，通过在“Thr-34”处磷酸化 BIRC5 来抵消 TRAIL/TNFSF10 诱导的细胞凋亡。这种调节作用至关重要地抑制 TRAIL/TNFSF10 触发的程序性细胞死亡，突出了异二聚体对抗凋亡信号传导的积极贡献。CDK15-CCNY Heterodimer 蛋白, Human (Sf9) 是重组的蛋白二聚体复合物，包含 CDK15-CCNY 异二聚体蛋白，由 Sf9 insect cells 表达，不带标签。

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1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 μg   询价  
100 μg   询价  

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描述

The CDK15ic protein, functioning as an antiapoptotic kinase, counteracts TRAIL/TNFSF10-induced apoptosis by phosphorylating BIRC5 at 'Thr-34'. This regulatory role crucially inhibits programmed cell death triggered by TRAIL/TNFSF10, highlighting the heterodimer's active contribution to antiapoptotic signaling. CDK15-CCNY Heterodimer Protein, Human (Sf9) is a recombinant protein dimer complex containing human-derived CDK15-CCNY Heterodimer protein, expressed by Sf9 insect cells , with tag free.
研究背景

CDK15ic 蛋白作为抗凋亡激酶发挥作用，通过催化 BIRC5 在“Thr-34”位点的磷酸化，主动减轻 TRAIL/TNFSF10 诱导的细胞凋亡。通过这种调节机制，异二聚体复合物在对抗细胞凋亡信号传导中发挥着至关重要的作用，从而有助于抑制 TRAIL/TNFSF10 触发的程序性细胞死亡。
种属

Human
表达系统

Sf9 insect cells
标签

Tag Free
蛋白编号

Q96Q40 (M1-W435)&Q8ND76 (M1-S341)
基因 ID

65061&219771
同用名
CDK15; CCNY; Cyclin-dependent kinase 15; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein; Cell division protein kinase 15; Serine/threonine-protein kinase ALS2CR7; Serine/threonine-protein kinase PFTAIRE-2; Cyclin-Y; Cyc-Y; Cyclin box protein 1; Cyclin fold protein 1; cyclin-X
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CDK15-CCNY Heterodimer Protein, Human (Sf9) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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