CEACAM1 蛋白, Rat (HEK293, His)

CEACAM1 protein is involved in the regulation of hepatic lipogenesis and inhibition of cell proliferation. It interacts with INSR to reduce fatty acid synthesis and with SHC1 to inhibit cell proliferation. CEACAM1 Protein, Rat (HEK293, His) is the recombinant rat-derived CEACAM1 protein, expressed by HEK293 , with C-His, C-10*His labeled tag. The total length of CEACAM1 Protein, Rat (HEK293, His) is 388 a.a., with molecular weight of 66-76 kDa.

CD31/PECAM-1 蛋白是一种关键的细胞粘附分子，在大多数炎症情况下对于白细胞跨内皮迁移 (TEM) 是不可或缺的。Tyr-690 在 TEM 中的关键作用体现在它参与 PECAM1 往返于侧缘回收区室 (LBRC) 的有效运输，这对于靶向迁移白细胞周围的 LBRC 膜至关重要。该蛋白参与跨同性相互作用，可能有助于通过细胞连接促进内皮细胞与细胞的粘附，而其与 CD177 的异嗜性相互作用在中性粒细胞的跨内皮迁移中起着至关重要的作用。PECAM1 的同种连接具有双重目的，通过传递分离信号来防止巨噬细胞介导的邻近活白细胞的吞噬作用，同时通过将凋亡白细胞束缚到吞噬细胞来促进巨噬细胞介导的对凋亡白细胞的吞噬作用。除了在细胞粘附中的作用外，CD31/PECAM-1 还调节缓激肽受体 BDKRB2 激活，并调节缓激肽和高渗休克诱导的内皮细胞中 ERK1/2 的激活。尽管具有多功能性，CD31/PECAM-1 对动脉粥样硬化易感性具有显着影响，但缺乏针对细胞凋亡的保护作用。这强调了 CD31/PECAM-1 在协调免疫和内皮细胞反应的各个方面的多方面功能。

Rat

HEK293

C-His;C-10*His

P16573 (Q35-S422)

81613  [NCBI]

QVTVDAVPPNVVEEKSVLLLAHNLPQEFQVFYWYKGTTLNPDSEIARYIRSDNMSKTGPAYSGRETIYSNGSLFFQNVNKTDERAYTLSVFDQQFNPIQTSVQFRVYPALQKPNVTGNNSNPMEGEPFVSLMCEPYTNNTSYLWSRNGESLSEGDRVTFSEGNRTLTLLNVRRTDKGYYECEARNPATFNRSDPFNLDVIYGPDAPVISPPDIYLHQGSNLNLSCHADSNPPAQYFWLINEKLQTSSQELFISNITTNNSGTYACFVNNTVTGLSRTTVKNITVFEPVTQPSIQITNTTVKELGSVTLTCFSKDTGVSVRWLFNSQSLQLTDRMTLSQDNSTLRIDPIKREDAGDYQCEISNPVSFRISHPIKLDVIPDPTQGNSGLS

66-76 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.