CEACAM6 蛋白, Human (His-SUMO)

The CEACAM6 protein is a cell surface glycoprotein that promotes calcium- and fibronectin-independent cell-cell adhesion and mediates homo- and heterosexual interactions with other carcinoembryonic antigen-related cell adhesion molecules. CEACAM6 Protein, Human (His-SUMO) is the recombinant human-derived CEACAM6 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of CEACAM6 Protein, Human (His-SUMO) is 286 a.a., with molecular weight of ~47.2 kDa.

CEACAM6 蛋白是一种细胞表面糖蛋白，在细胞粘附和肿瘤进展中发挥着关键作用。相互作用以不依赖于钙和纤连蛋白的方式发生，介导嗜同性和嗜异性细胞与其他癌胚抗原相关细胞粘附分子（如 CEACAM5 和 CEACAM8）的粘附。特别是，与 CEACAM8 的异嗜性相互作用发生在活化的中性粒细胞中，影响中性粒细胞与细胞因子活化的内皮细胞的粘附。在肿瘤进展的背景下，CEACAM6 作为癌基因，通过正向调节细胞迁移、与内皮细胞的粘附和侵袭。此外，它还通过诱导胰腺腺癌细胞和结直肠癌细胞对失巢凋亡的抵抗而促进转移级联反应。CEACAM6 形成同二聚体，通过其 Ig 样 V 型结构域参与同二聚化，并且还通过各自的 Ig 样 V 型结构域与 CEACAM8 形成异二聚体，突出了其在细胞粘附和癌症相关过程中的多方面作用。

Human

E. coli

N-6*His;N-SUMO

P40199 (K35-G320)

4680  [NCBI]

KLTIESTPFNVAEGKEVLLLAHNLPQNRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWVNGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDGPTISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQAHNSATGLNRTTVTMITVSG

Approximately 47.2 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.