CEBP delta/CEBPD 蛋白, Human (His-Myc)

The CEBP delta/CEBPD protein is a transcriptional activator that recognizes CCAAT and enhanced core motifs. It is critical for immune and inflammatory response genes and enhances IL6 transcription independently or together with CEBPB. CEBP delta/CEBPD Protein, Human (His-Myc) is the recombinant human-derived CEBP delta/CEBPD protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of CEBP delta/CEBPD Protein, Human (His-Myc) is 268 a.a., with molecular weight of ~43 kDa.

CEBP delta/CEBPD 蛋白充当转录激活剂，识别两个不同的 DNA 基序：许多启动子中发现的 CCAAT 同源性和增强子中普遍存在的增强核心同源性。该转录因子在调节与免疫和炎症反应相关的基因表达中发挥着至关重要的作用。CEBP δ 既作为同二聚体又作为异二聚体发挥作用，可独立增强 IL6 转录，并与 CEBPB 一起作为异二聚体。此外，它不仅可以与CEBPB形成稳定的异二聚体，还可以与CEBPA和CEBPE形成稳定的异二聚体。值得注意的是，CEBP delta 直接与 SPI1/PU.1 相互作用，并且这种相互作用不会影响每个伙伴的 DNA 结合特性。此外，CEBP delta 与 PRDM16 相互作用，进一步凸显了其在转录调控中的多功能作用。

Human

E. coli

N-10*His;C-Myc

P49716 (S2-R269)

1052  [NCBI]

SAALFSLDGPARGAPWPAEPAPFYEPGRAGKPGRGAEPGALGEPGAAAPAMYDDESAIDFSAYIDSMAAVPTLELCHDELFADLFNSNHKAGGAGPLELLPGGPARPLGPGPAAPRLLKREPDWGDGDAPGSLLPAQVAACAQTVVSLAAAGQPTPPTSPEPPRSSPRQTPAPGPAREKSAGKRGPDRGSPEYRQRRERNNIAVRKSRDKAKRRNQEMQQKLVELSAENEKLHQRVEQLTRDLAGLRQFFKQLPSPPFLPAAGTADCR

Approximately 43 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.