CFHR1 蛋白, Human (HEK293, His)

CFHR1, a key complement regulator, actively engages in the finely tuned complement system. Dimerized CFHR1 demonstrates avidity for tissue-bound complement fragments, challenging CFH. It also associates with lipoproteins, suggesting involvement in lipid metabolism. With a unique head-to-tail homodimeric structure, CFHR1 forms heterodimers with CFHR2 or CFHR5, showcasing its versatile role in complement-related processes. CFHR1 Protein, Human (HEK293, His) is the recombinant human-derived CFHR1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CFHR1 Protein, Human (HEK293, His) is 312 a.a., with molecular weight of 38-50 kDa.

CFHR1 成为补体调节复杂领域的关键人物，展示了它对这个精细调节系统的积极参与。在二聚化形式下，CFHR1 对组织结合的补体片段表现出显着的亲合力，有效挑战生理补体抑制剂 CFH。除了其调节能力之外，CFHR1 还表现出与脂蛋白结合的亲和力，暗示其在脂质代谢中的潜在作用。CFHR1 独特的结构排列包括头尾相连的同二聚体配置，并进一步与 CFHR2 或 CFHR5 形成异二聚体，强调其在补体相关过程的多方面编排中的多功能参与。

Human

HEK293

C-6*His

Q03591 (E19-R330)

3078  [NCBI]

EATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR

38-50 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 2 mM EDTA, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.