CFHR2 蛋白, Human (HEK293, His)

CFHR2, a key complement regulator, competently rivals CFH by avidly interacting with tissue-bound complement fragments. It also associates with lipoproteins, hinting at a role in lipid metabolism. With a distinctive head-to-tail homodimeric structure, CFHR2 forms heterodimers with CFHR1 or CFHR5, showcasing its versatile involvement in the regulatory dynamics of the complement system. CFHR2 Protein, Human (HEK293, His) is the recombinant human-derived CFHR2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CFHR2 Protein, Human (HEK293, His) is 252 a.a., with molecular weight of 31 & (33-36) kDa, respectively.

CFHR2 在复杂的补体调节领域占据中心地位。作为一个关键参与者，它与组织结合的补体片段进行积极的相互作用，展示了其与生理补体抑制剂 CFH 竞争的能力。此外，CFHR2 表现出与脂蛋白结合的倾向，表明其可能参与脂质代谢。更复杂的是，CFHR2 表现出独特的头尾同源二聚体结构，并与 CFHR1 或 CFHR5 形成异二聚体，强调了其在补体系统调节芭蕾中的多功能作用。

Human

HEK293

C-6*His

P36980 (E19-K270)

3080  [NCBI]

EAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQNGKLVYPSCEEK

31&(33-36) kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 200 mM NaCl, 2 mM EDTA, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.