1. 重组蛋白
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  3. CHN1 蛋白, Human (sf9)

CHN1 蛋白, Human (sf9)

目录号: HY-P75673
产品使用指南

CHN1 蛋白是 p21-rac 的 GTP 酶激活蛋白,充当佛波酯受体,对于组装神经元运动回路至关重要。它作为 EPHA4 的直接效应器,将 EPHA4 激活与 RAC1 调节联系起来。CHN1 与 EPHA4 的相互作用影响轴突引导信号通路,影响正常运动所需神经元回路的发育和组织。CHN1 蛋白, Human (sf9) 是重组的 CHN1 蛋白,由 Sf9 insect cells 表达,不带标签。CHN1 蛋白, Human (sf9) 全长 458 个氨基酸,分子量约为 ~45 kDa。

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描述

CHN1 protein, a GTPase-activating protein for p21-rac, acts as a phorbol ester receptor and is crucial in assembling neuronal locomotor circuits. It serves as a direct effector of EPHA4, linking EPHA4 activation to RAC1 regulation. CHN1's interaction with EPHA4 influences axon guidance signaling pathways, impacting the development and organization of essential neuronal circuits for proper locomotion. CHN1 Protein, Human (sf9) is the recombinant human-derived CHN1 protein, expressed by Sf9 insect cells , with tag free. The total length of CHN1 Protein, Human (sf9) is 458 a.a., with molecular weight of ~45 kDa.

研究背景

CHN1 是 p21-rac 的 GTP 酶激活蛋白,作为佛波酯受体,在神经元运动回路的组装中发挥关键作用。它在轴突引导中充当 EPHA4 的直接效应器,在 EPHA4 激活和 RAC1 调节之间形成关键联系。通过与 EPHA4 的相互作用,CHN1 有助于参与轴突引导的复杂信号通路,从而影响正常运动所必需的神经元回路的发育和组织。

种属

Human

表达系统

Sf9 insect cells

标签

Tag Free

蛋白编号

P15882 (A2-F459)

基因 ID
蛋白结构
N-term
CHN1 (A2-F459)
Accession # P15882
C-term
同用名
N-chimaerin; A-chimaerin; NC; CHN1; ARHGAP2; CHN
分子量

Approximately 45 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

CHN1 Protein, Human (sf9) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CHN1 Protein, Human (sf9)
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HY-P75673
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