CLEC4C 蛋白, Human (His-SUMO)

CLEC4C is a lectin-type cell surface receptor that plays a crucial role in antigen capture by dendritic cells. It specifically recognizes non-sialylated galactose-terminated biantennary glycans with the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. CLEC4C Protein, Human (His-SUMO) is the recombinant human-derived CLEC4C protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of CLEC4C Protein, Human (His-SUMO) is 169 a.a., with molecular weight of ~36.0 kDa.

CLEC4C 蛋白作为凝集素型细胞表面受体发挥作用，参与树突状细胞的抗原捕获。它特异性识别含有三糖表位 Gal(beta1-3/4)GlcNAc(beta1-2)Man 的非唾液酸化半乳糖封端的双触角聚糖。此外，CLEC4C 与血清 IgG 结合，并有效地将配体靶向抗原加工和肽装载区室，以呈递给 T 细胞。值得注意的是，它可能介导对浆细胞样树突状细胞中 IFN-α/β 表达诱导的有效抑制，并充当信号传导受体，激活蛋白酪氨酸激酶并动员细胞内钙。该蛋白质形成同二聚体，强调了其在细胞信号传导和免疫反应调节中的潜在重要性。

Measured by its binding ability in a functional ELISA. Immobilized CLEC4C protein at 2 μg/mL can bind human IgG, the EC₅₀ of human IgG is 3.358-4.383 ng/mL.

Human

E. coli

N-SUMO;N-6*His

Q8WTT0 (N45-I213)

170482  [NCBI]

NFMYSKTVKRLSKLREYQQYHPSLTCVMEGKDIEDWSCCPTPWTSFQSSCYFISTGMQSWTKSQKNCSVMGADLVVINTREEQDFIIQNLKRNSSYFLGLSDPGGRRHWQWVDQTPYNENVTFWHSGEPNNLDERCAIINFRSSEEWGWNDIHCHVPQKSICKMKKIYI

Approximately 36.0 kDa

• 
  Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm solution of PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.