CLEC4D 蛋白, Human (HEK293, His)

CLEC4D, a calcium-dependent lectin, operates as a pattern recognition receptor (PRR) in the innate immune system, discerning both damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) from bacteria and fungi. Recognizing alpha-mannans on C. albicans hyphae and mycobacterial trehalose 6,6'-dimycolate (TDM), CLEC4D forms a functional complex with the signaling adapter Fc receptor gamma chain/FCER1G, likely through its interaction with CLEC4E, in myeloid cells. Binding of TDM or C. albicans alpha-mannans to this receptor complex induces the phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, activating SYK, CARD9, and NF-kappa-B. This activation drives the maturation of antigen-presenting cells and influences antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. CLEC4D, when forming a heterodimer with CLEC6A, exhibits activity against fungal infections. Additionally, it functions as an endocytic receptor, suggesting a role in antigen uptake at the site of infection, either for antigen clearance or for processing and subsequent presentation to T-cells. The heterodimerization with CLEC4E and CLEC6A further highlights the dynamic and versatile nature of CLEC4D in immune surveillance and response mechanisms. CLEC4D Protein, Human (HEK293, His) is the recombinant human-derived CLEC4D protein, expressed by HEK293 , with N-His labeled tag. The total length of CLEC4D Protein, Human (HEK293, His) is 164 a.a., with molecular weight of 21-27 kDa.

CLEC4D 是一种钙依赖性凝集素，在先天免疫系统中充当模式识别受体 (PRR)，识别细菌和真菌中的损伤相关分子模式 (DAMP) 和病原体相关分子模式 (PAMP)。 CLEC4D 识别白色念珠菌菌丝上的 α-甘露聚糖和分枝杆菌海藻糖 6,6'-二霉菌酸酯 (TDM)，与信号转导接头 Fc 受体伽马链/FCER1G 形成功能复合物，可能是通过其与骨髓细胞中的 CLEC4E 相互作用。 TDM 或白色念珠菌 α-甘露聚糖与该受体复合物的结合会诱导 FCER1G 的免疫受体酪氨酸激活基序 (ITAM) 磷酸化，从而激活 SYK、CARD9 和 NF-kappa-B。这种激活会驱动抗原呈递细胞的成熟，并影响 T 细胞针对效应 T 辅助细胞 1 和 T 辅助细胞 17 细胞亚型的抗原特异性启动。 CLEC4D 与 CLEC6A 形成异二聚体时，表现出抗真菌感染的活性。此外，它还充当内吞受体，表明它在感染部位的抗原摄取中发挥作用，无论是用于抗原清除还是用于处理和随后呈递给 T 细胞。 CLEC4E 和 CLEC6A 的异二聚化进一步凸显了 CLEC4D 在免疫监视和反应机制中的动态和多功能性质。

Human

HEK293

N-His

Q8WXI8 (G52-N215)

338339  [NCBI]

21-27 kDa

Greater than 90% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.