COASY 蛋白, Human (His)

COASY Protein, a bifunctional enzyme, plays a pivotal role in catalyzing the fourth and fifth steps of the CoA biosynthetic pathway. The coaD domain facilitates phosphopantetheine adenylyltransferase activity for the fourth reaction, and the coaE domain drives dephospho-CoA kinase activity for the fifth reaction. COASY is crucial for regulating CoA biosynthesis, ensuring efficient synthesis of the vital cofactor involved in diverse cellular metabolic pathways. COASY Protein, Human (His) is the recombinant human-derived COASY protein, expressed by E. coli, with N-His labeled tag. The total length of COASY Protein, Human (His) is 269 a.a., with molecular weight of ~33 kDa.

COASY 蛋白作为双功能酶发挥作用，在催化 CoA 生物合成途径的第四和第五连续步骤中发挥关键作用。由 coaD 结构域编码的磷酸泛硫氨酸腺苷酰转移酶活性促进第四个反应，而由 coaE 结构域编码的去磷酸 CoA 激酶活性驱动该途径中的第五个反应。这种酶是 CoA 生物合成调节不可或缺的一部分，可能作为控制整个过程的关键点，确保 CoA 的正确和有效合成，CoA 是参与各种细胞代谢途径的重要辅助因子。

Human

E. coli

N-His

Q13057 (M296-D564)

80347  [NCBI]

Approximately 33 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.