1. 重组蛋白
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  3. COL4A1 蛋白, Human (His)

COL4A1蛋白是一种重要的IV型胶原成分,形成肾小球基底膜(GBM)的主要结构框架,具有独特的“鸡丝”网状结构。它与层粘连蛋白、蛋白聚糖和巢蛋白/巢蛋白配合维持GBM的结构完整性。COL4A1 蛋白, Human (His) 是重组的 COL4A1 蛋白,由 E. coli 表达,带有 C-His 标签。

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规格 价格 是否有货 数量
20 μg ¥1500 In-stock
50 μg ¥2800 询价
100 μg   询价  

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描述

COL4A1 protein is an important type IV collagen component that forms the main structural framework of the glomerular basement membrane (GBM) with a unique "chicken wire" mesh structure. It cooperates with laminin, proteoglycans and nestin/nesidin to maintain the structural integrity of GBM. COL4A1 Protein, Human (His) is the recombinant human-derived COL4A1 protein, expressed by E. coli, with C-His labeled tag.

研究背景

COL4A1 蛋白是 IV 型胶原蛋白的关键成分,构成肾小球基底膜 (GBM) 的主要结构框架,与层粘连蛋白、蛋白聚糖和巢蛋白/巢蛋白共同形成独特的“鸡丝”网络。此外,Arresten 由 COL4A1 的 C 端 NC1 结构域组成,对血管生成和肿瘤形成具有有效的抑制作用。值得注意的是,抗血管生成活性存在于 COL4A1 的 C 末端一半,它选择性地阻碍内皮细胞增殖、迁移和管形成。COL4A1 的这种双重作用凸显了其不仅在维持 GBM 结构完整性方面的重要性,而且还通过 Arresten 的活性调节血管生成和肿瘤发展等关键过程。

种属

Human

表达系统

E. coli

标签

C-His

蛋白编号

P02462 (30G-167P)

基因 ID

1282

蛋白长度

Partial

同用名
Arresten; BSVD; COL4A1; COL4A1 NC1 domain; COL4A2; COL4A3; COL4A4; COL4A5; collagen alpha-1(IV) chain
分子量

Approximately 25 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

性状

无菌粉末

组分

Lyophilized from a 0.22 μm filtered solution of PBS, 6% Trehalose, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

COL4A1 Protein, Human (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
COL4A1 Protein, Human (His)
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HY-P704062
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