COL4A1 蛋白, Human (His)

COL4A1 protein is an important type IV collagen component that forms the main structural framework of the glomerular basement membrane (GBM) with a unique "chicken wire" mesh structure. It cooperates with laminin, proteoglycans and nestin/nesidin to maintain the structural integrity of GBM. COL4A1 Protein, Human (His) is the recombinant human-derived COL4A1 protein, expressed by E. coli, with C-His labeled tag.

COL4A1 蛋白是 IV 型胶原蛋白的关键成分，构成肾小球基底膜 (GBM) 的主要结构框架，与层粘连蛋白、蛋白聚糖和巢蛋白/巢蛋白共同形成独特的“鸡丝”网络。此外，Arresten 由 COL4A1 的 C 端 NC1 结构域组成，对血管生成和肿瘤形成具有有效的抑制作用。值得注意的是，抗血管生成活性存在于 COL4A1 的 C 末端一半，它选择性地阻碍内皮细胞增殖、迁移和管形成。COL4A1 的这种双重作用凸显了其不仅在维持 GBM 结构完整性方面的重要性，而且还通过 Arresten 的活性调节血管生成和肿瘤发展等关键过程。

Human

E. coli

C-His

P02462 (30G-167P)

1282

Partial

Approximately 25 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.