Collectin-11/CL-K1 蛋白, Mouse (HEK293, His)

Collectin-11/CL-K1 Protein is a secreted protein that activates tyrosine kinase receptors (EGFR, HER3) and ERK, JNK, and AKT signaling pathways to promote cell proliferation. Collectin-11/CL-K1 Protein plays an important role in innate immunity and apoptosis. Collectin-11/CL-K1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Collectin-11/CL-K1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Collectin-11/CL-K1 Protein, Mouse (HEK293, His) is 246 a.a., with molecular weight of 30-35 kDa.

Collectin-11 是一种分泌蛋白，通过与微生物上的碳水化合物抗原结合，并通过募集甘露糖结合凝集素(MBL) 相关丝氨酸蛋白酶 (MASPs) 激活补体，在先天免疫中发挥重要作用。Collectin-11 可激活酪氨酸激酶受体 (EGFR、HER3) 和 ERK、JNK、AKT 信号通路素瘤细胞增殖具有直接刺激作用。Collectin-11 通过以钙不依赖的方式与凋亡细胞表面的 DNA 结合并激活补体来响应这种结合，从而在细胞凋亡中发挥作用。Collectin-11 通过诱导先天免疫防御，在尿路致病性大肠杆菌 (UPEC) 诱导的尿路感染 (UTI) 中发挥保护作用。

Mouse

HEK293

C-6*His

Q3SXB8-1 (Q27-L272)

71693  [NCBI]

QQTTEDACSVQILVPGLKGDAGEKGDKGAPGRPGRVGPTGEKGDMGDKGQKGTVGRHGKIGPIGAKGEKGDSGDIGPPGPSGEPGIPCECSQLRKAIGEMDNQVTQLTTELKFIKNAVAGLRETESKIYLLVKEEKRYADAQLSCQARGGTLSMPKDEAANGLMASYLAQAGLARVFIGINDLEKEGAFVYSDRSPMQTFNKWRSGEPNNAYDEEDCVEMVASGGWNDVACHITMYFMCEFDKENL

30-35 kDa

Greater than 90% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.