1. 重组蛋白
  2. Complement System
  3. Complement Component 5
  4. Complement Component 5a
  5. Complement C5/C5a 蛋白, Pig (P.pastoris, His)

Complement C5/C5a 蛋白, Pig (P.pastoris, His)

目录号: HY-P71719
产品使用指南

补体 C5/C5a 蛋白是补体系统的组成部分,参与免疫反应和炎症。它被裂解生成 C5a,一种有效的促炎介质。补体 C5/C5a 蛋白在免疫调节中的作用及其作为治疗靶点的潜力使其成为治疗炎症性疾病和自身免疫性疾病的有希望的候选者。Complement C5/C5a 蛋白, Pig (P.pastoris, His) 是重组的 补体 C5/C5a 蛋白,由 P. pastoris 表达,带有 N-His 标签。Complement C5/C5a 蛋白, Pig (P.pastoris, His) 全长 74 个氨基酸,分子量约为 ~10.6 kDa。

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描述

Complement C5/C5a Protein, a component of the complement system, is involved in the immune response and inflammation. It is cleaved to generate C5a, a potent pro-inflammatory mediator. Complement C5/C5a Protein's role in immune regulation and its potential as a therapeutic target make it a promising candidate for the treatment of inflammatory disorders and autoimmune diseases. Complement C5/C5a Protein, Pig (P.pastoris, His) is the recombinant pig-derived Complement C5/C5a protein, expressed by P. pastoris , with N-His labeled tag. The total length of Complement C5/C5a Protein, Pig (P.pastoris, His) is 74 a.a., with molecular weight of ~10.6 kDa.

研究背景

补体 C5a 蛋白源自补体 C5 的蛋白水解降解,是局部炎症过程中的关键介质。C5AR1、C5a 与其受体结合后会引发多种反应,包括细胞内钙的释放、平滑肌收缩、血管通透性增加以及肥大细胞和嗜碱性白细胞释放组胺。作为一种有效的趋化因子,C5a 积极刺激多形核白细胞的迁移,引导它们向炎症部位移动。与 C5AR1 的相互作用对于协调这些免疫调节作用至关重要。

种属

Pig

表达系统

P. pastoris

标签

N-His

蛋白编号

P01032 (1M-74R)

基因 ID

414437  [NCBI]

蛋白结构
N-term
His
C5a (1M-74R)
Accession # P01032
C-term
同用名
C5; Complement C5a anaphylatoxin
氨基酸序列

MLQKKIEEEAAKYKYAMLKKCCYDGAYRNDDETCEERAARIKIGPKCVKAFKDCCYIANQVRAEQSHKNIQLGR

分子量

Approximately 10.6 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

Complement C5/C5a Protein, Pig (P.pastoris, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Complement C5/C5a Protein, Pig (P.pastoris, His)
目录号:
HY-P71719
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