Coxsackievirus A16 VP1 蛋白 (295a.a, sf9, Fc)

Coxsackievirus A16 (CVA16) can cause hand-foot-and-mouth disease (HFMD). CVA16 is a small, non-enveloped, icosahedral particle containing a single-stranded, positive-sense viral RNA genome of approximately 7.4 kb in length. CVA16 can be cleaved by viral proteases into 4 structural (VP1 to VP4) and 7 nonstructural (2A to 2C, and 3A to 3D) proteins. CVA16 interacts with its host receptors (cell surface heparan sulfate glycosaminoglycans and SCARB2 as its uncoating receptor) to enter into susceptible cells. Upon binding, CVA16 mature virions may transform to an uncoating intermediate state. Coxsackievirus A16 VP1 Protein is one of the capsid subunit protein of cleaved CVA16^[1][2]. Coxsackievirus A16 VP1 Protein (295a.a, sf9, Fc) is the recombinant Virus-derived Coxsackievirus A16 VP1 protein, expressed by Sf9 insect cells , with C-hFc labeled tag. The total length of Coxsackievirus A16 VP1 Protein (295a.a, sf9, Fc) is 295 a.a., with molecular weight of ~59.5 KDa.

柯萨奇病毒 A16 (CVA16) 可引起手足口病（HFMD），这是一种常见的急性传染病。CVA16 是一种小的、无包膜的二十面体颗粒，含有长度约为 7.4 kb 的单链正义病毒 RNA 基因组。CVA16 可被病毒蛋白酶切割成 4 种结构蛋白 (VP1 至 VP4) 和 7 种非结构蛋白 (2A 至 2C 和 3A 至 3D)^[1]。因此，柯萨奇病毒 A16 VP1 蛋白是裂解的 CVA16 的衣壳亚基蛋白之一。
CVA16 与其宿主受体 (细胞表面硫酸乙酰肝素糖胺聚糖和 SCARB2，也称为 LIMP-2 作为其脱壳受体) 相互作用，进入易感细胞。结合后，CVA16 成熟病毒颗粒可能转变为脱衣中间状态，称为“135S 样颗粒”或“A颗粒”，具有衣壳膨胀、袋因子丢失和扩大的两倍开口的特征^[2]。

Virus

Sf9 insect cells

C-hFc

AAA50478 (G568-K862)

1461111  [NCBI]

Approximately 59.5 kDa.

Greater than 85% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.