CRKL 蛋白, Human

CRKL protein mediates intracellular signal transduction, interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1, and plays a role in erythropoietin receptor and phosphoinositide signaling. It also binds to DOCK2 and DOCK5, suggesting regulation of guanine nucleotide exchange factors. CRKL Protein, Human is the recombinant human-derived CRKL protein, expressed by E. coli , with tag free.

CRKL 蛋白参与介导细胞内信号的转导，表明其在细胞信号传导途径中的作用。它与酪氨酸磷酸化的 EPOR 和 INPP5D/SHIP1 相互作用，表明它参与与促红细胞生成素受体信号传导和磷酸肌醇信号传导相关的途径。此外，CRKL 通过其第一个 SH3 结构域与 DOCK2 和 DOCK5 相互作用，突出了其在调节鸟嘌呤核苷酸交换因子中的潜在作用。该蛋白进一步与磷酸化的 CBLB 和 IRS4 结合，表明它参与了与细胞增殖和胰岛素受体信号传导相关的途径。此外，CRKL 与 BCAR1/CAS 和 NEDD9/HEF1 相互作用，表明其参与与细胞粘附和迁移相关的信号级联反应。这些不同的相互作用强调了 CRKL 在细胞内传递信号方面的多功能性。

Human

E. coli

Tag Free

P46109 (M1-E303)

1399

Full Length

Approximately 33.9 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of 50 mM HEPES, pH7.5, 200 mM NaCl, 20% glycerol, 1 mM DTT.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.