1. 重组蛋白
  2. Immune Checkpoint Proteins CD Antigens
  3. Inhibitory Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins Dendritic Cell CD Proteins
  4. CTLA-4 CD152/CTLA-4
  5. CTLA-4 蛋白, Guinea pig (P.pastoris, His)

CTLA-4 蛋白, Guinea pig (P.pastoris, His)

目录号: HY-P71986
COA 产品使用指南

CTLA-4 蛋白是一种有效的抑制性受体,通过与其配体 CD80 和 CD86 强烈结合(超过 CD28 的亲和力),在抑制 T 细胞反应中发挥着至关重要的作用。这种增强的亲和力使 CTLA-4 能够充当主要的负调节因子,维持免疫稳态并防止 T 细胞过度激活。CTLA-4 及其配体之间的平衡对于免疫调节至关重要。CTLA-4 蛋白, Guinea pig (P.pastoris, His) 是重组的 CTLA-4 蛋白,由 P. pastoris 表达,带有 C-6*His 标签。CTLA-4 蛋白, Guinea pig (P.pastoris, His) 全长 125 个氨基酸,分子量约为 ~18.0 kDa。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
Free Sample   Apply now  
2 μg ¥480 In-stock
10 μg ¥1350 In-stock
50 μg ¥3800 In-stock
100 μg   询价  

* Please select Quantity before adding items.

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

CTLA-4 protein, a potent inhibitory receptor, plays a crucial role in suppressing T-cell responses by binding strongly to its ligands CD80 and CD86, surpassing the affinity of CD28. This heightened affinity allows CTLA-4 to act as a major negative regulator, maintaining immune homeostasis and preventing excessive T-cell activation. The balance between CTLA-4 and its ligands is pivotal for immune regulation. CTLA-4 Protein, Guinea pig (P.pastoris, His) is the recombinant CTLA-4 protein, expressed by P. pastoris , with C-6*His labeled tag. The total length of CTLA-4 Protein, Guinea pig (P.pastoris, His) is 125 a.a., with molecular weight of ~18.0 kDa.

研究背景

CTLA-4 蛋白作为一种重要的抑制性受体,在抑制 T 细胞反应中发挥着至关重要的作用。其抑制作用源于 CTLA-4 与其天然 B7 家族配体 CD80 和 CD86 表现出的极强亲和力,超过了其对应的刺激性辅助受体 CD28 的亲和力。凭借这种增强的亲和力,CTLA-4 在 T 细胞激活和免疫反应的复杂协调中充当主要的负调节因子。CTLA-4 及其配体介导的刺激信号和抑制信号之间的微妙平衡对于维持免疫稳态和防止 T 细胞过度或异常激活至关重要。

生物活性

The ED50 as determined by its ability to bind Mouse B7-1 in functional ELISA is less than 0.4 μg/mL.

种属

Others

表达系统

P. pastoris

标签

C-6*His

蛋白编号

H0VUB1 (A37-D161)

基因 ID

100725760  [NCBI]

蛋白结构
N-term
CTLA-4 (A37-D161)
Accession # H0VUB1
6*His
C-term
同用名
Cytotoxic T-lymphocyte associated protein 4; CTLA4
氨基酸序列

AMHVAQPAVVLASSRGVASFECEYASSHNANEVRVTVLQQVASRTTEICAATYTVERELAFPEDSACAGTSSGTRVNLTIQGLRAADTGLYICKVELMYPPPYFVGTGNGTQIYVIDPEPCPDSD

分子量

Approximately 18.0 kDa

纯度
  • Greater than 90% as determined by reducing SDS-PAGE.
性状

溶液.

组分

Supplied as a 0.2 μm filter solution of 1xPBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

N/A.

保存条件 & 期限

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

运输条件

Shipping with dry ice.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
CTLA-4 Protein, Guinea pig (P.pastoris, His)
目录号:
HY-P71986
需求量: