DC-SIGN/CD209 蛋白, Human (HEK293, Fc)

The DC-SIGN/CD209 protein is expressed on immature dendritic cells (DC) and is an important pathogen recognition receptor that initiates primary immune responses. It mediates endocytosis and subsequent degradation of pathogens within the lysosomal compartment. DC-SIGN/CD209 Protein, Human (HEK293, Fc) is the recombinant human-derived DC-SIGN/CD209 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of DC-SIGN/CD209 Protein, Human (HEK293, Fc) is 346 a.a., with molecular weight of ~78 kDa.

DC-SIGN/CD209 蛋白表达于未成熟树突状细胞 (DC) 表面，是关键的病原体识别受体，在启动初级免疫反应中发挥着至关重要的作用。该受体参与病原体的内吞作用，导致其随后在溶酶体室内降解。在此过程之后，DC-SIGN 返回细胞膜表面，通过 MHC II 类蛋白将病原体衍生的抗原呈递给静息 T 细胞，从而触发适应性免疫反应。在 DC 上，它充当 ICAM2 和 ICAM3 的高亲和力受体，与甘露糖样碳水化合物结合。值得注意的是，DC-SIGN 可能充当 DC 滚动受体，通过与内皮 ICAM2 相互作用，促进 DC 前体从血流跨内皮迁移到组织。此外，它似乎通过与 DC 和 T 细胞之间形成的免疫突触内 T 细胞上的 ICAM3 结合来调节 DC 诱导的 T 细胞增殖。

Human

HEK293

N-hFc

Q9NNX6 (Q59-A404)

30835  [NCBI]

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Approximately 78 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.