DCBLD2 蛋白, Human (HEK293, His)

DCBLD2 Protein is a novel platelet membrane receptor that recruits TRAF6 through EGFR phosphorylation and stimulates AKT to promote tumorigenesis. The DCBLD2 Protein has multiple functions during development as well as in vascular and tumor biology, such as influencing cell proliferation and tumorigenesis. DCBLD2 Protein, Human (HEK293, His) is the recombinant human-derived DCBLD2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of DCBLD2 Protein, Human (HEK293, His) is 462 a.a., with molecular weight of 80-110 kDa.

DCBLD2 编码盘状蛋白、CUB 和LCCL 结构域蛋白2，也叫内皮细胞和平滑肌细胞源性神经匹林样蛋白(ESDN) 和/或Charcot-Leyden 晶体蛋白假基因1 (CLCP1)。DCBLD2 基因是一种I 型跨膜受体，与神经匹林样跨膜支架受体(如血管内皮生长因子(VEGF) 受体和信号蛋白) 具有结构相似性，在发育过程以及血管和肿瘤生物学中具有多种功能。DCBLD2 是一种新型血小板膜受体，在血管重构中起关键作用，影响血管平滑肌细胞(VSMC) 增殖，一些癌症的细胞运动和转移以及神经元定位。DCBLD2 通过EGFR 磷酸化招募TRAF6 并刺激AKT 促进肿瘤发生。

Human

HEK293

C-6*His

Q96PD2 (Q67-A528)

131566  [NCBI]

QQGDGCGHTVLGPESGTLTSINYPQTYPNSTVCEWEIRVKMGERVRIKFGDFDIEDSDSCHFNYLRIYNGIGVSRTEIGKYCGLGLQMNHSIESKGNEITLLFMSGIHVSGRGFLASYSVIDKQDLITCLDTASNFLEPEFSKYCPAGCLLPFAEISGTIPHGYRDSSPLCMAGVHAGVVSNTLGGQISVVISKGIPYYESSLANNVTSVVGHLSTSLFTFKTSGCYGTLGMESGVIADPQITASSVLEWTDHTGQENSWKPKKARLKKPGPPWAAFATDEYQWLQIDLNKEKKITGIITTGSTMVEHNYYVSAYRILYSDDGQKWTVYREPGVEQDKIFQGNKDYHQDVRNNFLPPIIARFIRVNPTQWQQKIAMKMELLGCQFIPKGRPPKLTQPPPPRNSNDLKNTTAPPKIAKGRAPKFTQPLQPRSSNEFPAQTEQTTASPDIRNTTVTPNVTKDVA

80-110 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.