2. 重组蛋白
  3. Enzymes & Regulators
  4. Transferases (EC 2)
  5. DCK/Deoxycytidine kinase 蛋白, Human (P. pastoris, His)

DCK/Deoxycytidine kinase 蛋白, Human (P. pastoris, His)

目录号: HY-P700584
产品使用指南 技术支持

DCK/脱氧胞苷激酶蛋白可有效磷酸化脱氧核糖核苷，包括脱氧胞苷、脱氧鸟苷和脱氧腺苷，表现出广泛的底物特异性，无手性选择性。作为一种不可或缺的酶，DCK 在磷酸化核苷类似物方面发挥着至关重要的作用，这在抗病毒和化疗治疗中至关重要。DCK/Deoxycytidine kinase 蛋白, Human (P. pastoris, His) 是重组的 DCK/脱氧胞苷激酶蛋白，由 P. pastoris 表达，带有 C-6*His 标签。

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描述

DCK/deoxycytidine kinase protein can effectively phosphorylate deoxyribonucleosides, including deoxycytidine, deoxyguanosine and deoxyadenosine, showing broad substrate specificity and no chiral selectivity. As an indispensable enzyme, DCK plays a crucial role in phosphorylating nucleoside analogues, which is critical in antiviral and chemotherapeutic treatments. DCK/Deoxycytidine kinase Protein, Human (P. pastoris, His) is the recombinant human-derived DCK/Deoxycytidine kinase protein, expressed by P. pastoris , with C-6*His labeled tag.
研究背景

DCK 被称为脱氧胞苷激酶，通过有效磷酸化脱氧核糖核苷（包括脱氧胞苷、脱氧鸟苷和脱氧腺苷）来展示其酶促能力。该激酶具有广泛的底物特异性，不会表现出基于底物手性的选择性。其重要性延伸至成为常用作抗病毒和化疗剂的各种核苷类似物磷酸化不可或缺的酶。DCK 催化核苷磷酸化的能力在细胞过程中起着至关重要的作用，并有助于基于核苷类似物的治疗的疗效。
种属

Human
表达系统

P. pastoris
标签

C-6*His
蛋白编号

P27707 (M1-L260)
基因 ID
蛋白结构
N-term
DCK (M1-L260)
Accession # P27707
6*His
C-term
蛋白长度

Full Length
中文名
DCK 蛋白/Deoxycytidine 激酶蛋白
同用名
rHuDeoxycytidine kinase/DCK, His-T7; Deoxycytidine Kinase; dCK; DCK
氨基酸序列

MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL

预测分子量
31.6 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

DCK/Deoxycytidine kinase Protein, Human (P. pastoris, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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